Antipsychotic Flashcards
Schizophrenia results from an imbalance of
DA activity between various cortical regions
Over-activity of DA in the limbic system leads to
Agitation and Hallucinations
Diminished DA in some cortical areas results in
Cognitive Deficits and Withdrawal behavior
Anti-psychotic Medications (pharmacodymamics) alter
blocking the postsynaptic dopamine receptors/DA antagonist
High Potency Traditional Antipsychotic Drugs
Haloperidol (“Schizo’s see Halo’s”)
Fluphenazine
Low Potency Traditional Antipsychotic Drugs
Chlorpomazine and Thioridazine (Both end in zine)
High Potency Traditional Drugs have what side effects
Extra-pyramidal/motor *acute dystonic reactions, akathisia, Pseudo-Parkinsonism, Tardive Dyskinesia
Low Potency Traditional Drugs have what side effects
Sedation and anticholinergic effects of dry mouth, constipation, urinary retention
Atypical “2nd Generation” Anti-psychotic Meds include
Risperidone (odd people whisper alone “one”)
Clozapine
Olanzapine
Atypical drugs have what major side effect
Metabolic including serious CV and endocrine probs such as weight gain, increased lipids, DM
Tardative Dyskinesia
Side effect of the high potency traditional drugs that may disappear in weeks to years with drug removal but may be permanent in other people
Bipolar Affective Disorder is defined as
episodes of mood swings unrelated to life events
Bipolar meds include
Eskalith (Eskimos are bipolar)
Depakane
Adverse effects of biopolar/lithium meds include
Ataxia! (PT related), tremor, sedation, DM, edema
