Antiprotozoan therapy Flashcards
1
Q
What is the mechanism of Chloroquine?
A
Blocks detoxification of heme into hemozoin. Heme accumulates and is toxic to plasmodia.
2
Q
What are the clinical uses of Choloroquine?
A
Treatment of plasmodial species other than P. falciparum. For life threatening malaria, use quinidine in US or artisunate.
3
Q
What toxicities should we be aware of for Chloroquine?
A
Retinopathy.
