Antiparasitics Flashcards
Name antiparasitic agents
Albendazole Mebendazole Praziquantel Ivermectin Diethylcarbamazine Nitazoxanide
Which antiparasitic drug binds to the cyoskeleton protein beta tubuling?
Albendazole
Mebendazole
What species are benzamidazoles active against?
Nematodes Ascariasis Trichuriasis Enterobiasis Hook worms Trichinella spp Toxocara spp Cestodes
Name side effects of benzamidazoles
Reversible alopecia
Leukopenia
Which antiparasitic drug causes structural changes in the parasite’s teguments?
Praziquantel
What species is praziquantel active against?
Schistosomiasis Cystcercosis Chlonorchiasis Tapeworms Paragonimiasis
What species is praziquantel NOT active against?
Fasciola hepatica
Which antiparasitic drug causes an influx of chloride ions leading to hyperpolarisation?
Ivermectin
What species is ivermectin active against?
Onchocerca volvulus Strongyloides stercoralis Ectoparasites Lice Scabies
Name side effects of ivermectin
Host response toxicity
Fatal encephalopathy
Mazzotti syndrome
Which antiparasitic drug alters parasitic membranes?
Diethylcarbamazine
Which antiparasitic drug is an antiprozoal, antihelminthic and antibacterial?
Nitazoxanide
Name 4-amino quinolones
Chloroquine
Hyroxychloroquine
Amodiaquine
Name 8-amino quinolones
Primaquine
Name cinchona alkaloids
Quinine
Quinidine
Name synthetic quinolones
Halofantrine
Mefloquine
Name signs of chloroquine toxicity
GIT symptoms Retinal pigmentation Blurred vision ECG changes Neuropsychiatric symptoms
Name signs of amodiaquine toxicity
Agranulocytosis
Aplastic anemia
Drug-induced hepatitis
Name signs of cinchona alkaloid toxicity
Cinchonism Hypoglycemia Haemolysis Agranulocytosis Thrombotyopenia
Which drug is used to prevent relapses of P. ovale and P. vivax and why?
Primaquine
Active against hypnozoites
What is the issue with primaquine in a patient with G6PD deficiency?
Induces haemolysis
Why is malarone effective for antimalarial prophylaxis and treatment?
Active against both sexual + asexual P. falciparum
