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Pharmacology > Antiparasitics > Flashcards

Antiparasitics Flashcards

1
Q

Name antiparasitic agents

A 
Albendazole
Mebendazole
Praziquantel
Ivermectin
Diethylcarbamazine
Nitazoxanide
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2
Q

Which antiparasitic drug binds to the cyoskeleton protein beta tubuling?

A

Albendazole

Mebendazole

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3
Q

What species are benzamidazoles active against?

A 
Nematodes
Ascariasis
Trichuriasis
Enterobiasis
Hook worms
Trichinella spp
Toxocara spp
Cestodes
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4
Q

Name side effects of benzamidazoles

A

Reversible alopecia

Leukopenia

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5
Q

Which antiparasitic drug causes structural changes in the parasite’s teguments?

A

Praziquantel

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6
Q

What species is praziquantel active against?

A 
Schistosomiasis
Cystcercosis
Chlonorchiasis
Tapeworms
Paragonimiasis
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7
Q

What species is praziquantel NOT active against?

A

Fasciola hepatica

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8
Q

Which antiparasitic drug causes an influx of chloride ions leading to hyperpolarisation?

A

Ivermectin

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9
Q

What species is ivermectin active against?

A 
Onchocerca volvulus
Strongyloides stercoralis
Ectoparasites
Lice
Scabies
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10
Q

Name side effects of ivermectin

A

Host response toxicity
Fatal encephalopathy
Mazzotti syndrome

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11
Q

Which antiparasitic drug alters parasitic membranes?

A

Diethylcarbamazine

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12
Q

Which antiparasitic drug is an antiprozoal, antihelminthic and antibacterial?

A

Nitazoxanide

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13
Q

Name 4-amino quinolones

A

Chloroquine
Hyroxychloroquine
Amodiaquine

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14
Q

Name 8-amino quinolones

A

Primaquine

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15
Q

Name cinchona alkaloids

A

Quinine

Quinidine

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16
Q

Name synthetic quinolones

A

Halofantrine

Mefloquine

17
Q

Name signs of chloroquine toxicity

A 
GIT symptoms
Retinal pigmentation
Blurred vision
ECG changes
Neuropsychiatric symptoms
18
Q

Name signs of amodiaquine toxicity

A

Agranulocytosis
Aplastic anemia
Drug-induced hepatitis

19
Q

Name signs of cinchona alkaloid toxicity

A 
Cinchonism
Hypoglycemia
Haemolysis
Agranulocytosis
Thrombotyopenia
20
Q

Which drug is used to prevent relapses of P. ovale and P. vivax and why?

A

Primaquine

Active against hypnozoites

21
Q

What is the issue with primaquine in a patient with G6PD deficiency?

A

Induces haemolysis

22
Q

Why is malarone effective for antimalarial prophylaxis and treatment?

A

Active against both sexual + asexual P. falciparum

Pharmacology (32 decks)

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