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Drugs > Antiparasitics > Flashcards

Antiparasitics Flashcards

1
Q

Antiprotozoal

A

Chloroquine
Arthemether/lumefantrine
Primaquine
Metronidazole
Paromomycin

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2
Q

Antihelminthic

A

Albendazole
Ivermectin

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3
Q

Vivax and ovale species of malaria can relase due to

A

Dormant hypnozoites in the liver

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4
Q

Antimalarial prophylaxis

A

Chloroquine
Primaquine

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5
Q

Treatment of active or latent malaria

A

Arthemether/lumefantrine
Chloroquine
Primaquine

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6
Q

Clincical maleria cure (blood stage)

A

Chloroquine
Artemisinins

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7
Q

Liver stage malaria (radical cure) for relapsin infection

A

Primaquine

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8
Q

Prophylactic malarial agent properties

A

Orally effective
Long half lives
Low toxicity

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9
Q

chloroquine mechanism

A

Inhibits bio crystallization

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10
Q

chloroquine resistance

A

PfCRT efflux transporter prevents drug accumulation

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11
Q

chloroquine theraputic uses

A

Prophylaxis
Treatment during pregnancy

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12
Q

High doses of chloroquine may cause

A

Pruritis
Headache
GI effects
CV toxicity

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13
Q

Artemether (oral) mechanism

A

Unclear
Not useful for prophylaxis

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14
Q

Artemether uses

A

In combination with lumefantrine
First line treatment of falciparum

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15
Q

Artemether adverse reactions

A

Neurotoxicity
Embryotoxicity

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16
Q

Primaquine mechanism

17
Q

Primaquine uses

A

Perscripted with cloroquine to cure vivax/ovale
For terminal or primary prophylaxis

18
Q

Primaquine adverse effects

A

Hemolytic anemia in people with G6PD defiency (contraindicated)
Contraindicated in all pregnant females

19
Q

_ agents are not absorbed

20
Q

Metronidazole mechanism

A

DNA damaging metabolite

21
Q

Metronidazole uses

A

Systemic
Amebiasis
Anaerobic bacterial infections

22
Q

Paromomycin mechanism

A

Aminoglycoside

23
Q

Paromomycin uses

A

Luminal
Asymptomatic amebiasis
Amebic colitis/dysentery
Alternative to metrondiazole in pregnancy
Leshmanias

24
Q

Paromomycin adverse effects

A

GI distress

25
Q

Albendazole mechanism

A

Interupts beta tubultin
Disrupts nematode motility

26
Q

Albendazole uses

A

Enterobiasis infections
Cestoad/roundworm infections

27
Q

Albendazole adverse effects

A

Teratogenic
Liver toxicity
Bone marrow supression

28
Q

Ivermectin mechanism

A

Immobilization of tonic mucle paralysis
Hyperpolorization of neuronal membrane

29
Q

Ivermectin uses

A

Nematode and arthropod infections
Onchocerciasis, lymphatic filariasis, intestional nematoodes
Scabies
Head lice

30
Q

Ivermectin adverse rections

A

Mazzotti reaction
Teratogenic

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