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Medical Pharmacolog > Antineoplastics > Flashcards

Antineoplastics Flashcards

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USMLE® Step 1 flashcards
1
Q

DOC for choriocarcinoma

Also used for breast and lung CA

A

Methotrexate

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2
Q

Teratogenic
Crystallization in tubules
Stomatitis

A

Methotrexate

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3
Q

Decreases side effects of Methotrexate

A

Leucovorin

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4
Q

Most specific for s phase

For AML only

A

Cytarabine

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5
Q

DOC for colon CA

also used for breast, ovarian and head and neck CA

A

5-FU

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6
Q

GI ulcerations

A

5-FU

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7
Q

Inhibits microtubule assembly

A

Vinca alkaloids (vincristine, vinblastine, vinorelbine)

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8
Q

Used for ewing’s sarcoma, neuroblastoma, wilm’s timor

Neurotoxic

A

VinCristine

C- childhood malignancies

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9
Q

Inhibits microtubule disassembly

Used for solid tumors

A

Taxanes (paclitaxel, docetaxel)

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10
Q

Neurotoxic taxane

A

Docetaxel

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11
Q

Inhibits topoisomerase II

A

Podophyllotoxins (etoposide, teniposide)

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12
Q

Inhibits topoisomerase I

A

Camptothecins (-tecan, tecONE)

Irinotecan
Topotecan

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13
Q

Camptothecin for metastatic colon CA

A

Irinotecan

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14
Q

Antineoplastics that are cytotoxic, mutagenic, carcinogenic

A

Alkylating agents

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15
Q

Hemorrhagic cystitis

A

Cyclophosphamide (tx: MESNA)

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16
Q

Ototoxic and nephrotoxic

A

Platinum analogs: cisplatin, carboplatin

17
Q

Used for brain tumors

A

Nitrosureas : lomustine, carmustine

18
Q

Pulmonary fibrosis

A

Busulfan
Bleomycin
Amiodarone

19
Q

Cardiotoxic

A

Anthracycline: doxorubicin, daunorubicin

Tx: dexrazoxane

20
Q

Competitive inhibitor of estradiol

A

Tamoxifen

21
Q

Causes endometrial CA

A

Tamoxifen

22
Q

DOC for ER positive breast CA

A

Tamoxifen

23
Q

Inhibits androgen translocation to the nucleus

For prostate CA

A

Flutamide

24
Q

Tyrosine kinase inhibitor

A

Imatinib

25
Q

Congestive heart failure, fluid retention

A

Imatinib

26
Q

Used for metastatic breast CA that is positive for HER2/NEU receptor

A

Trastuzumab

27
Q

G2 specific antibiotic

A

Bleomycin

28
Q

Inhibits S phase of cell cycle

A

Antimetabolites:

  • methotrexate
  • purine analogs– mercaptopurine, thioguanine
  • pyrimidine analogs– 5-fluorouracil, cytarabine, gemcitabine

Medical Pharmacolog (4 decks)

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