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Medical Pharmacolog > Antifungal > Flashcards

Antifungal Flashcards

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USMLE® Step 1 flashcards
1
Q

Creates pores in fungal cell membrane

A

Polyenes (amphotericin b, nystatin)

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2
Q

Broad spectrum polyene

DOC for systemic mycoses

A

Amphotericin B

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3
Q

Side effect of amphotericine B

A

Nephrotoxic (acute tubular acidosis)
Acute febrile reaction
Anemia
Phlebitis

Fast infusions causes hypotension and muscle spasm

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4
Q

DOC for oral candidiasis

A

Nystatin

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5
Q

Squalene accumulation

Deposits in keratin

A

Terbinafine

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6
Q

Terbinafine is used in all tinea infections except

A

Tinea versicolor (Tx: selenium sulfide, topical azoles)

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7
Q

Inhibits ergosterol synthesis (C14 demethylase)

A

Azoles

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8
Q

Inhibits androgen and adrenal steroid synthesis

A

Ketoconazole

- used for candidiasis and dermatophytes

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9
Q

DOC for cryptococcal meningitis

Also used for invasive mycoses

A

Fluconazole

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10
Q

Azoles for superficial mycoses

A

Clotrimazole
Miconazole
Econazole

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11
Q

Side effect of azoles

A

Hepatotoxic

Enzyme inhibitor

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12
Q

Arrests fungal mitosis at metaphase
Accumulates in keratin
Used for tinea capitis

A

Griseofulvin

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13
Q

Porphyria

A

Griseofulvin

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14
Q

Active metabolite is -FU
Always used with amphotericin b
For systemic candidiasis and cryptococcal meningitis

A

Flucytosine

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15
Q

Causes bone marrow depression, alopecia

A

Flucytosine

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16
Q

Fungal cell wall inhibitor
Inhibits B(1-2) glycan synthesis
Used for invasive candidiasis

A

Echinocandins (-fungin)

Medical Pharmacolog (4 decks)

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