Antineoplastic Hormones and Related Drugs

Question 1

Abiraterone acetate

Answer 1

17alpha hydroxylase inhibitor. Prevents testosterone synthesis. 2nd, 3rd, 4th line of treatment when others don’t work.

Question 2

When is Bicalutamide administered?

Answer 2

For first few weeks to prevent effect of the GnRH agonists which initially stimulate the production of testosterone and dihydrotestosterone.

Question 3

What is Aminoglutethimide?

Answer 3

Prostate cancer treatment. Blocks pregnenolone synthesis.

Question 4

What are the Aromatase inhibitors?

Answer 4

Anastrazole, Letrozol. Prevent conversion of testosterone to estradiol and androstenedione to estrone. Exemestane irreversibly inhibits the enzyme.

Question 5

What are the Selective Estrogen Receptor Modulators?

Answer 5

SERMs. Tamoxifen, Raloxifene, and Tormifene. Agonists on some estrogen receptors and antagonists at others. Termed modulators.

Question 6

What drug is an agonist on the uterus?

Answer 6

Tamoxifen

Question 7

What drug is an antagonist on the bone?

Answer 7

Fulvestrant

Question 8

How does progesterone prevent pregnancy?

Answer 8

It can’t prevent pregnancy after ovulation, it can only prevent ovulation to begin with. If patient has already ovulated, drug has no effect.

Question 9

What are the combinations used to treat breast CA?

Answer 9

5-FU, Doxorubicin (anthracyclines), cyclophosphamide (FAC). Cyclophosphamide, Methotrexate and 5-FU (CMF). Paclitaxel. Tamoxifen, Tormefene and Fulvestrant. Anastrozole, Letrozole and Exemestane. Trastuzumab.