Antineoplastic Hormones Flashcards
Goserelin
MOA
TU
MOA: GnRH agonist, desensitizes testosterone axis
TU: prostate and breast ca
Leuprolide
MOA
TU
MOA: GnRH agonist, desensitizes testosterone axis
TU: prostate and breast ca
Degerelix
MOA
TU
MOA: GnRH antagonist
TU: prostate and breast ca
Finasteride
MOA
TU
MOA: 5α reductase inhibitor
TU: prostate ca
Abiraterone
MOA
MOA: prevents testosterone synthesis
Bicalutamide
MOA
TU
MOA: testosterone receptor antagonist
TU: given w/ agonist to hinder initial growth burst
Flutamide
MOA
TU
MOA: testosterone receptor antagonist
TU: given w/ agonist to hinder initial growth burst
Anastrazole
MOA
TU
MOA: reversible aromatase inhibitor
TU: breast ca
Exemestane
MOA
TU
MOA: irreversible aromatase inhibitor
TU: breast ca
Fulvestrant
MOA
MOA: complete estrogen antagonist in all tissues
Tamoxifen
MOA
MOA: partial agonist (works like antagonist) in breast, agonist in uterus and bone
Raloxifene
MOA
MOA: antagonist in breast and uterus, agonist in bone
Tormifene
MOA
MOA: antagonist in breast, unknown in uterus and bone
