Antimycobacterials

Question 1

RNA polymerase inhibitor
RAMPS up microsomal cyt p450
RED/orange body fluids
Rapid RESISTANCE if used alone

Answer 1

Rifabutin (Favored in HIV, d/t less cyt p450 +)

Rifampin (ramps up cyt p450, butin does not)

Question 2

prophylaxis for meningococcal and HIB

Answer 2

Rifampin

Question 3

resistance from decreased drug binding to RNA pol

Answer 3

Rifampin

Question 4

Needs bacterial Catalase peroxidase (KAT G) to convert to active metabolite>
decreases syntehsis of mycolic acids

Answer 4

Isoniazid

Question 5

only agent used as solo prophylaxis for TB

Answer 5

isoniazid

Question 6

INH injures….

Answer 6

Injures…
Neurons (prevented w/ B6)
Hepatocytes

…has diff half life in fast vs. slow acetylators

Question 7

underexpession of KATG

Answer 7

resistance to isoniazid

Question 8

prodrug converted to active compound by pyrazinoic acid that is used to tx myobacterium tuberuclosis

Answer 8

Pyrazinamide (INTRACELLULAR)

hyperuricemia
hepatoxicity

Question 9

BLOCKS arabinosyl transferase>

decrased CARBOHYDRATE POLYMERIZATION

Answer 9

ethambutol

Question 10

causes optic neuropathy (RED GREEN color blidnness)

Answer 10

EYEtham butol