Antimicrobials, -fungals, -virals Flashcards
Fungal cell wall synthesis inhibitors
Echinocandins
Bind fungal cell membrane ergosterol
- Amphotericin B
- Nystatin
Inhibition of ergosterol+lanosterol synthesis
- Terbinafine
- Naftifine
Inhibition of ergosterol synthesis
Azoles
Inhibition of nucleic acid synthesis (fungal)
5-flucytosine
Diseuption of mitotic spindle and inhibition of fungal mitosis
Griseofulvin
Miscellaneous (fungal)
Ciclopirox
Antibiotics: polyenes (fungal)
- Amphotericin
- Nystatin
Antibiotics: Heterocyclic benzofuran (fungal)
Griseofulvin
Antimetabolite (fungal)
Flucytosine
Azoles: imidazoles (fungal)
- Ketoconazole
- Clotrimazole
- Oxiconazole
- Miconazole
Azoles: triazoles (fungal)
- Fluconazole
- Itraconazole
- Voriconazole
- Posaconazole
Allylamines (fungal)
- Terbinafine
- Naftitine
Echinocandins (fungals)
- Caspofungin
- Anidulafungin
- Micafungin
1) Systemic antifungals for systemic infections
- Amphotericin B, liposomal Amph. B
- Flucytosine (5-fluorocytosine)
- Azoles
- Echinocandins
2) Systemic antifungals for mucocutaneous infections
- Terbinafine
- Griseofulvin
3) Local antifungals
- Nystatin
- (Allylamines)
- (Amorolphin)
- (Ciclopirox)
- (Azoles)
DNA/RNA synthesis inhibitors (viral)
1) Nucleoside/nucleotide analogues (NRTIs)
2) Non competitive inhibitors (NNRTIs, foscarnet, HCV)
Entry inhibitors (viral)
- Maraviroc
- Enfuvirtid
Uncoating inhibitors (viral)
Amantadin
Other viral enzyme inhibitors
- Kinase inhibitor (CMV)
- Terminase inhibitor (CMV)
- Protease inhibitor (HIV, HCV)
- Integrase inhibitor (HIV)
- Neuroaminidase inhibitor (influenza)
Immunological agents (viral)
- Interferon α
- Imiquimod
- Palivizumab
Drug that can block tubular secretion
Probenecid
Combinations beta lactams and beta lactamase inhibitors (3)
Amoxicillin - clavulanic acid
Ampicillin - sulbactam
Piperacillin - tazobactam
