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Pharmacology 1st semester > Antimicrobials, -fungals, -virals > Flashcards

Antimicrobials, -fungals, -virals Flashcards

1
Q

Fungal cell wall synthesis inhibitors

A

Echinocandins

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2
Q

Bind fungal cell membrane ergosterol

A
  • Amphotericin B

- Nystatin

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3
Q

Inhibition of ergosterol+lanosterol synthesis

A
  • Terbinafine

- Naftifine

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4
Q

Inhibition of ergosterol synthesis

A

Azoles

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5
Q

Inhibition of nucleic acid synthesis (fungal)

A

5-flucytosine

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6
Q

Diseuption of mitotic spindle and inhibition of fungal mitosis

A

Griseofulvin

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7
Q

Miscellaneous (fungal)

A

Ciclopirox

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8
Q

Antibiotics: polyenes (fungal)

A
  • Amphotericin

- Nystatin

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9
Q

Antibiotics: Heterocyclic benzofuran (fungal)

A

Griseofulvin

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10
Q

Antimetabolite (fungal)

A

Flucytosine

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11
Q

Azoles: imidazoles (fungal)

A
  • Ketoconazole
  • Clotrimazole
  • Oxiconazole
  • Miconazole
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12
Q

Azoles: triazoles (fungal)

A
  • Fluconazole
  • Itraconazole
  • Voriconazole
  • Posaconazole
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13
Q

Allylamines (fungal)

A
  • Terbinafine

- Naftitine

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14
Q

Echinocandins (fungals)

A
  • Caspofungin
  • Anidulafungin
  • Micafungin
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15
Q

1) Systemic antifungals for systemic infections

A
  • Amphotericin B, liposomal Amph. B
  • Flucytosine (5-fluorocytosine)
  • Azoles
  • Echinocandins
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16
Q

2) Systemic antifungals for mucocutaneous infections

A
  • Terbinafine

- Griseofulvin

17
Q

3) Local antifungals

A
  • Nystatin
  • (Allylamines)
  • (Amorolphin)
  • (Ciclopirox)
  • (Azoles)
18
Q

DNA/RNA synthesis inhibitors (viral)

A

1) Nucleoside/nucleotide analogues (NRTIs)

2) Non competitive inhibitors (NNRTIs, foscarnet, HCV)

19
Q

Entry inhibitors (viral)

A
  • Maraviroc

- Enfuvirtid

20
Q

Uncoating inhibitors (viral)

A

Amantadin

21
Q

Other viral enzyme inhibitors

A
  • Kinase inhibitor (CMV)
  • Terminase inhibitor (CMV)
  • Protease inhibitor (HIV, HCV)
  • Integrase inhibitor (HIV)
  • Neuroaminidase inhibitor (influenza)
22
Q

Immunological agents (viral)

A
  • Interferon α
  • Imiquimod
  • Palivizumab
23
Q

Drug that can block tubular secretion

A

Probenecid

24
Q

Combinations beta lactams and beta lactamase inhibitors (3)

A

Amoxicillin - clavulanic acid
Ampicillin - sulbactam
Piperacillin - tazobactam

Pharmacology 1st semester (7 decks)

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