Antidepressants, anxiolytics & mood stabilizers

Question 1

Fluoxetine

Answer 1

SSRI

Question 2

Paroxetine

Answer 2

SSRI

Question 3

Sertraline

Answer 3

SSRI

Question 4

Citalopram

Answer 4

SSRI

Question 5

Venlafaxine

Answer 5

SSNRI (dose-dependent)

Question 6

Duloxetine

Answer 6

SSNRI

Question 7

Treat serotonin syndrome

Answer 7

Cyproheptadine - 5HT2 blocker

Question 8

Imipramine

Answer 8

TCA

Question 9

Desipramine

Answer 9

TCA - imipramine derivative

Question 10

Clomipramine

Answer 10

TCA - imipramine derivative

- Good for OCD

Question 11

Amitriptyline

Answer 11

TCA

- Block NET + SERT

Question 12

Nortriptyline

Answer 12

TCA

- Block NET + SERT

Question 13

Tranylcypromine

Answer 13

MAO inhibitor

• Non-selective
• Irreversible

Question 14

Phenelzine

Answer 14

MAO inhibitor

• Non-selective
• Irreversible

Question 15

Isocarboxacid (sketchy)

Answer 15

MAO inhibitor

Question 16

Selegiline

Answer 16

MAO B inhibitor

• Selective
• Irreversible

Question 17

Treat hypertensive crisis from tyramine toxicity

Answer 17

Phentolamine (alpha 1 & -2 antagonist)

Question 18

Buproprion

Answer 18

Atypical antidepressant

• Antagonise (NET &) DAT
• Good for depression and smoking cessation w/o sexual dysfunction
• Contraindicated in eating disorder patients => seizures

Question 19

Mirtazapine

Answer 19

Atypical antidepressant

• Block alpha 2, 5HT2, 5HT3, H1 R’s
• Release 5HT and NE
• Good for patients with depression and insomnia
• SE: sedation, weight gain
• No sexual dysfunction

Question 20

Trazodone

Answer 20

Atypical antidepressant

• Antagonises 5HT2 and inhibit reuptake
• Block alpha 1 and H1
• SE: priapism, orthostatic hypotension, sexual dysfunction, serotonin syndrome

Question 21

Lithium

Answer 21

Mood stabilizers

• Treat bipolar disorder (mania/depression) - acute and maintenance
• Narrow TI

Question 22

Antiepileptics as mood stabilizers

Answer 22

1) Valproate
2) Carbamazepine
3) Lamotrigine
4) Clonazepam

Question 23

Trimipramine

Answer 23

TCA

- Higher sedative

Question 24

Maprotiline

Answer 24

Tetracyclic antidepressant

Very similar to TCAs, but higher affinity to NERT

Question 25

Apoxapine

Answer 25

Tetracyclic antidepressant

Very similar to TCAs, but higher affinity to NERT

Question 26

Escitalopram

Answer 26

SSRI

Question 27

Fluvoxamine

Answer 27

SSRI

- Rather for MDD and OCD

Question 28

Desvenlafaxine

Answer 28

SSNRI

Question 29

Milnaciprine/levomilnaciprine

Answer 29

SSNRI

• Higher affinity for SERT
• Indications: also fibromyalgia

Question 30

Reboxetine

Answer 30

SNRI

Question 31

Atomoxetine

Answer 31

SNRI

- Indication ADHD

Question 32

5HT R antagonists and reuptake inhibitors

Answer 32

Antidepressants

1) Trazodone (RI, 5HT2A antagonist)
2) Nefazodone (RI, 5HT2A antagonist)
* Hepatotoxic
3) Vilazodone (RI, 5HT1A partial ag)
4) Vortioxetine (RI, antagonise 5HT3A and 5HT7, partial agonist to 5HT1A)

Question 33

5HT2,3 and alpha2 antagonists and NE reuptake inhibitors

Answer 33

Antidepressants

1) Mirtazapine (also bind H1)
2) Mianserine

Question 34

Melatonin (MT 1 and -2) agonist and 5HT2C antagonist

Answer 34

Agomelatine

• Antidepressant, not frequently used
• Weight gain

Question 35

Moclobemide

Answer 35

Selective reversible MAO-A inhibitor (RIMA)