Antimicrobial Stewardship Flashcards
define mechanism of action
how a drug inhibits or kills bacteria
define spectrum of activity
which bacteria the drug is able to cover
does cidal or static require more drug?
static
define cidal
kills bacteria on its own and requires less drug to do so
define static
inhibits future growth of bacteria and require more drug and immune system assistance
what are 3 parameters we can use to optimize the way antibiotics kill bacteria?
- Time > MIC
- Cmax > MIC (max concentration above the MIC)
- AUC/MIC
drug concentration needs to be above the ___ for as long as possible
MIC
which drugs need to be above the MIC?
time-dependent killers
are beta lactams cidal or static?
cidal
true or false. You want to optimize time above the MIC with beta-lactams
True
list some beta-lactam drugs
penicillins, cephlasporins, carbapenemes, aztreonam (monobactam)
what routes can penicillin be given?
IV, IM, or oral
what is the drug of choice for susceptible enterococcus and listeria?
aminopenicillin
what are some examples of antistaphylcoccal penicillins?
-Nafcillin
-oxacillin
-dicloxacillin
which drug has no activity against enterococcus?
cephlasporins
Augmentin is a combination of what drugs? (PO)
amoxycillin and clavulate
Unasyn is a combination of which drugs? (IV)
ampicillin and sulbactam
what is unasyn used for?
bite wounds
Zosyn is a combination of which drugs?
piperacillin and tazobactam
which drug is known as vitamin z?
zosyn
what broad spectrum treatment is given if infection is suspected in the ER (hint: it covers MRSA and pseudomonas. You must monitor kidney function)
vancomycin and zosyn
Which drug class has no activity against enterococcus?
cephlasporins
Which cephlasporin is primarily used against gram negative bacteria but can treat some gram positive infections like strep?
Cefepime
as you move from 1st generation cephlasporins down, you lose gram ___ and gain gram ____ activity. The exception is the ___ generation
positive; negative; 5th (covers MRSA but not pseudomonas)
which drug combination is used for the most drug-resistant bacteria?
cephlasporins and beta-lactamase inhibitors
do cephlasporins + beta-lactamase inhibitors have acctivity against enterococcus?
No
List 2 cephlsporin + beta lactamase inhibitor drug combos
-ceftolozane/tazobactam (zerbaxa)
-ceftazidime/avibactam (Avycaz)
which carbapenems are seen most often?
entrapenem and meropenem
is entrapenem broad or narrow?
narrow
which carbapenem has a high rate of causing seizures?
Imipenem. It is reserved for infections with unique activity/nocardia
all carbapenems have the possibility to cause seizures by
lowering the threshold to have a seizure
Which carbapenem can treat APE (acinetobacter, pseudomonas, and enterococcus) and which carbapenem can’t?
Mertapenem can; ertapenem can’t
Which drugs are carbapenems?
-ertapenem (Invanz)
-Doripenem (doribax)
-Meroapenem (Merrem)
-Imipenem/Cilastatin (primaxin)
Do not use ___ ___ with carbapenems
valproic acid
aztreonam has gram ___ activity only
negative
Which drug has an inhaled form which is typically used for the cystic fibrosis population which are normally colonized with pseudomonas?
Aztreonam
Aztreonam combined with ____ could treat carbapenemase resistant infections
Avibactam
True or false. Aztreonam is used a lot.
False. It is not used a lot because of resistance.
Are fluroquinolones time or concentration dependent?
concentration
what is the mechanism of action for fluroquinolones?
inhibit DNA gyrase, resulting in DNA breakage
What year was the first fluroquinolone introduced?
1964
what are some potential side effects of fluoroquinolines?
-ruptures or tears of the aortta
-hypoglycemic risks
-psyhciatric risks
-joint pain, tendon rupture, anxiety, depression, altered mental status, peripheral neuropathy
What is the PK/PD of beta lactams?
T>MIC (optimize time above the MIC)
what is the PK/PD of fluroquinolones?
AUC: MIC
What is the PK/PD of aminoglycosides?
Cmax/MIC
What is the mechanism of action of aminoglycosides?
inhibits protein synthesis at the level of the ribosome
what are some ADEs of aminoglycosides?
nephrotoxicity, ototoxicity (kidneys and hearing affected… think of the meme)
True or false. Pharmacy doses aminoglycosides in a patient specific manner and they are almost always used in combination with something else
True
Aminoglycosides are almost always used for gram ____ infections
negative
what are aminoglycosides usually used to treat?
resistance or infection of the heart
what is the mechanism of action for macrolides?
they are static and inhibit protein synthesis at the ribosome
What are some ADEs of macrolides?
QTc prolongation, GI upset
with which drug do we see resistance because it is used to treat viral infections like colds?
azithromycin
what is the mechanism of action for sulfonamides?
interferes with bacterial folic acid synthesis (static)
Bactrim (the oral option for MRSA) is a combination of which drugs?
sulfamethoxozole and trimethoprim
what are some ADEs of sulfonamides?
rashes, dermatolic reactions
-monitor potassium, serum creatinine, and CBC
what is the mechanism of action of tetracyclines?
inhibit protein synthesis at the ribosome (statcic)
what is the most commonly prescribed tetracycline?
doxycycline
what are some ADEs of tetracyclines?
tooth discoloration (in children under 8), esophagitis (take with a full glass of water and sit up for at least half hour otherwise it can errode your esophagus, nausea, and photosensitivity
which drugs are not used for tick borne illness?
tetracyclines
Which drugs are not given to pregnant women to not disrupt dentition of children in utero?
tetracyclines
when in doubt
doxy it out (given to treat odd infection if they can’t figure out the infection)
glycopeptides and lipoglycopeptides are used for gram ___ infections
positive
vancomycin is used to treat which MDRO?
MRSA
what drug class does vancomycin fall under?
glycopeptides
describe some characteristics of vancomycin
-vitamin v
-mostly concentration dependent
-dosed in a patient specific manner
-Red man syndrome (not an allergy; infuse the drug slowly to prevent)
-harsh on kidneys
Which drugs are lipoglycopeptides?
dalbavancin and oritavancin
what are some characteristics of dalbavancin and oritavancin?
-longer half life
-1-2 dose treatment for skin infections
-can avoid hospital admission for IV treatment
-not always sure how to use them because they are newer
what does Linezolid treat and what must be monitored?
-gram positive and VRE
-Monitor platelets (patients are at risk of bleeding) and serotoninergic interactions
what does Daptomycin treat and what must be monitored?
-gram positive and VRE
-monitor CPK and statin use
-CPK can cause muscle pain and urine discoloration if it builds up in blood too much
What does Clindamycin treat?
-gram positive mostly
-some gram negative anaerobes
-causes antibiotic associated diarrhea and c. diff
Are IV drugs normally cidal or static?
cidal