AntiMicrobial proteins

Question 1

() proteins enhance innate defense by:
-Attacking microorganisms (), or
-Hindering microorganisms’ ability to ()

Answer 1

Antimicrobial
directly
reproduce

Question 2

2 important are

Answer 2

Interferons, Complement

Question 3

(): family of immune modulating proteins
-Cells infected with viruses can secrete IFNs that “()” healthy neighboring cells
-IFNs enter neighboring cells, stimulating production of proteins that block viral reproduction and degrade viral RNA
IFNs activate () cells and macrophages, so they indirectly fight cancer

Answer 3

Interferons
warn
NK

Question 4

-Cascade ofabout 20 blood proteins
-Leads to destruction of () substances
Activation enhances inflammation and also directly destroys microorganisms
Part of both innate and adaptive defenses

Answer 4

Commplement
foreign

Question 5

Complement Pathways
() pathway: Antibody activated (Adaptive)
() pathway: Bind directly to foreign antigen (Innate)

Answer 5

Classical
Alternative

Question 6

Cell () begins when:
(/) complex (MAC) inserts into cell’s membrane
-The MAC is a complex of 4 complement proteins that binds to the () membrane of pathogens (germs & foreign invaders)
-Causes influx of water and eventual lysis of microorganism
-Pathogen germ cell “swells” to the point of exploding

Answer 6

lysis
Membrane attack
plasma

Question 7

()
Abnormally high body temperature that is systemic response to invading microorganisms
Leukocytes and macrophages exposed to foreign substances secrete ()

Answer 7

Fever
pyrogens

Question 8

Benefits of moderate fever
-Causes liver and spleen to sequester () and zinc (needed by microorganisms)
-Increases () rate, which increases rate of repair
High fevers in children and infants can cause ()

Answer 8

iron
metabolic
Seziures