Antilipemic Drugs Flashcards
1
Q
LDLs
A
store cholesterol in the blood
2
Q
HDLs
A
recycle cholesterol (so they’re good)
3
Q
LDL levels
A
good: <100mg/dL
moderate: <200mg/dL
high: <300mg/dL (risk for coronary heart disease)
4
Q
Triglycerides
A
stored energy, too much can lead to diabetes
5
Q
Triglyceride levels
A
Mild: 150-199mg/dL
Moderate: 200-499mg/dL
Severe: >500mg/dL
6
Q
HMG-CoA reductase inhibitors indications
A
- Atherosclerotic cardiovascular disease (CVD)
- LDL >190
- some diabetes patients
7
Q
Rhabdomyolysis
A
- muscle protein breakdown
- may lead to acute renal failure and death
- pt report muscle soreness or changes in urine color
7
Q
HMG-CoA reductase inhibitor AKA
A
statins or HMGs
7
Q
Statins AE
A
- GI disturbances
- Rash
- HA
- Myopathy leading to rhabdomyolysis*
8
Q
Intensity levels of statins
A
High: lower LDL by 50%
Moderate: lower by 30-49%
Low: lower by <30%
9
Q
Bile acid sequestrants precautions
A
- take other drugs 1h before or 4-6h after
- high doses decrease the absorption of vitamins A, D, E, and K ( fat-soluble vitamins)
10
Q
B vitamin niacin (vitamin B3, nicotinic acid)
A
- requires a higher dose to decrease LDL
- cause flushing (start with a low dose to avoid this)
11
Q
Fibric acid derivatives
A
misc antilipemic
12
Q
Cholesterol absorption inhibitor
A
misc antilipemic
13
Q
Garlic, flax, omega-3 fatty acids
A
misc antilipemic
