Anti-Ulcer Drugs Flashcards
Ch.7 GI
1
Q
Peptic Ulcer Disease (PUD)
A
- gastric or duodenal ulcers
- digestion of mucosa by pepsin (enzyme)
2
Q
Helicobacter pylori (H. pylori)
A
- found in GI tract of patients with ulcers
- treated with proton pump inhibitor and clarithromycin and amoxicillin/metronidazole or PPI, bismuth subsalicylate, and tetracyline and metronidazole
3
Q
Types of acid controlling drugs
A
PPIs
H2 Antagonists
Antacids
4
Q
Poton Pump Inhibitors (PPIs) MOA
A
- bind to potassium-ATPase
- block hydrogen ions
- Inhibit proton pump
5
Q
Proton pump function
A
- responsible for 90% of secretion of HCL
-creates a achlorhydric environment
6
Q
PPIs used for
A
- erosive esophagitis
- active ulcers
7
Q
omeprazole (prilosec), lansoprazole, esomeprazole, rabeprazole drug class
(suffix -prazole)
A
PPIs (anti-ulcer)
8
Q
PPI AE
A
- predisposition to GI infx
- osteoporosis
- pneumonia
- Mg depletion
9
Q
PPI interactions
A
- increase levels of diazepam and phenytoin
- warfarin: increase risk of bleeding
- absorption of…
10
Q
cimetidine, famotidine, drug class
(suffix -tidine)
A
H2 Receptor antagonists (anti-ulcers)
11
Q
H2 receptor antagonists MOA
A
block H2 receptors
12
Q
H2 receptor antagonists AE
A
- CNS AE in elderly
- impotence and gynecomastia
13
Q
H2 receptor antagonists nursing implications
A
…
14
Q
Antacids MOA
A
- neutralize acids
- promote mucosal defenses
- inhibits pepsin to help w/ px
15
Q
Antacids contraindications
A
