Anti-Ulcer Drugs Flashcards
Ch.7 GI
Peptic Ulcer Disease (PUD)
- gastric or duodenal ulcers
- digestion of mucosa by pepsin (enzyme)
Helicobacter pylori (H. pylori)
- found in GI tract of patients with ulcers
- treated with proton pump inhibitor and clarithromycin and amoxicillin/metronidazole or PPI, bismuth subsalicylate, and tetracyline and metronidazole
Types of acid controlling drugs
PPIs
H2 Antagonists
Antacids
Poton Pump Inhibitors (PPIs) MOA
- bind to potassium-ATPase
- block hydrogen ions
- Inhibit proton pump
Proton pump function
- responsible for 90% of secretion of HCL
-creates a achlorhydric environment
PPIs used for
- erosive esophagitis
- active ulcers
omeprazole (prilosec), lansoprazole, esomeprazole, rabeprazole drug class
(suffix -prazole)
PPIs (anti-ulcer)
PPI AE
- predisposition to GI infx
- osteoporosis
- pneumonia
- Mg depletion
PPI interactions
- increase levels of diazepam and phenytoin
- warfarin: increase risk of bleeding
- absorption of…
cimetidine, famotidine, drug class
(suffix -tidine)
H2 Receptor antagonists (anti-ulcers)
H2 receptor antagonists MOA
block H2 receptors
H2 receptor antagonists AE
- CNS AE in elderly
- impotence and gynecomastia
H2 receptor antagonists nursing implications
…
Antacids MOA
- neutralize acids
- promote mucosal defenses
- inhibits pepsin to help w/ px
Antacids contraindications
Antacids implications
sucralfate, misoprostol, simethicone drug class
Misc acid meds (anti-ulcer)
Sucralfate MOA
- local mucosal protection
- stimulates mocous, bicarb, prostaglandins
- liquid bandage
- sulfate ions bind to ulcers
- limits pepsin contact
Sucralfate implications
- 1h before meals and bed
- avoid using w/ antacids
Misoprostal (Cytotec) MOA
- prevent gastric ulcer in NSAIDS users
- prostaglandin E analogue
Misoprostal (Cytotec) implications
- avoid in pregnancy
- give with food
Simethicone (Mylicon) MOA
- gas reduction
Simethicone (Mylicon) implications
- no AE
- take after meals
- still do a diet change to reduce gas
