antihypertensives Flashcards

1
Q

htn is a chronic disorder affecting ___ million adults in the US

A

50-60

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2
Q

HTN inc risk of?

A

MI, HF, cerebral infarction and hemorrhage

renal disease

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3
Q

what are the 2 main determinants in BP?

A

CO (systolic pressure) and peripheral vascular resistance (diastolic pressure)

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4
Q

what is auto regulation?

A

ability of body tissues to regulate own blood flow

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5
Q

what are some nutritional needs of tissue that cause auto regulation?

A

lack of o2

cellular metb by-products

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6
Q

what is the response to hypotension?

A

SNS stimulated
adrenal medulla secretes epi and norepinephrine
angiotensin II and aldosterone are formed
kidneys retain fluid
bp is inc

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7
Q

what is the response to htn?

A

inc renal secretion
fluid loss dec circulating vol which
dec CO which dec arterial BP which dec BP

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8
Q

what are the tissue factors important in auto regulation?

A

histamine, bradykinin, serotonin, and prostaglandins

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9
Q

what is defined as htn? (values)

A

Systolic pressure >140 mm Hg

Diastolic pressure >90 mm Hg

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10
Q

there is primary and secondary htn- what is the % of primary?

A

90-95

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11
Q

what does secondary htn result from?

A

renal, endocrine, or CNS disorders or from meds

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12
Q

normal bp values?

A

Normal = systolic <120 and diastolic 80–89

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13
Q

pre-htn values?

A

systolic 120–139 or diastolic 80–89

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14
Q

stage 1 htn?

A

systolic 140–159 or diastolic 90–99

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15
Q

stage 2 htn?

A

systolic >160 or diastolic >100

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16
Q

htn effect on heart?

A

inc cardiac workload

causing myocardium hypertrophy and eventually HF

17
Q

initial symp from Htn?

A

initially, may produce no symp and eventually target organ damage
heart, brain, kidneys, eyes

18
Q

htn emergencies causes?

A

Extension of malignant HTN, cerebral hemorrhage, dissecting aortic aneurysm, renal disease, etc.

19
Q

symptoms of htn emergencies?

A

Severe HA, N/V, visual disturbances, neurologic disturbances, disorientation,  level of consciousness (LOC)

20
Q

htn meds?

A

Angiotensin-converting enzyme (ACE) inhibitors (i.e. captopril)
Angiotensin II receptor blockers (ARBs) (i.e. losartan)
Antiadrenergics (i.e. doxazosin)
Calcium channel blockers (i.e. varapamil)
Diuretics (i.e. Hydrochlorothiazide, Furosemide, Spironolactone)
Direct vasodilators (i.e. nitroprusside)

21
Q

lifestyle mods to dec htn?

A

Weight and sodium intake reduction
Regular physical activity
Moderate EtOH intake
Smoking cessation

22
Q

if the first htn med fails do you inc dose or change med?

A

change med

23
Q

how many meds are htn patients usually on?

A

2+