Antihypertensives

Question 1

alpha 2 adrenergic agonist

Answer 1

clonidine

methyldopa

Question 2

alpha 2 adrenergic agonist mechanism of action

Answer 2

• stimulate receptors in Brain stem and autonomic regulation of cardiovascular system
• neurons stop releasing norepinephrine
• decrease sympathetic output

Question 3

Are alpha 2 adrenergic agonist 1st line drug HTN?

Answer 3

NO, reduces BP but doesn’t reduce M/M

Question 4

Clonidine therapeutic uses

Answer 4

HTN emergencies can chew clonidine and swallow
Tourette’s disorder
ADHD adjunct
withdrawal symptoms (nicotine, opiates, benzo’s, alcohol)

Question 5

Methylodopa therapeutic uses

Answer 5

Drug of Choice for Pregnancy induced HTN

Question 6

alpha 2 adrenergic agonist adverse effects

Answer 6

orthostatic hypotension
dizziness
headache
rebound fluid retention-add a diuretic
impaired ejaculation

Question 7

alpha 2 adrenergic agonist Warnings

Answer 7

abrupt withdrawal causes severe rebound HTN

Question 8

alpha 1 blocker

Answer 8

doxazosin
alfuzosin
terazosin
tamsulosin
prazosin

Question 9

alpha 1 blocker Mechanism of action

Answer 9

HTN- vasodilation of vasculature

BPH- relax smooth muscle of bladder neck and prostate

Question 10

Alpha 1 blocker therapeutic uses

Answer 10

BPH- urinary retnetion

Raynaud’s disase

Question 11

Are alpha 1 blockers a 1st line drug for HTN?

Answer 11

NO- don’t reduce M/M

Question 12

alpha 1 blocker adverse effects

Answer 12

Orthostatic hypotension “First Dose Effect”
reflex tachycardia
sodium and water retention

Question 13

alpha 1 blocker drug interactions

Answer 13

hypotention when used with vardenafil and sildenafil

Alfuzosin contraindicated with CYP3A4 inhibitors