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CVS pharmacology > Antihypertensive Drugs 2 > Flashcards

Antihypertensive Drugs 2 Flashcards

1
Q

Direct renin inhibitors

A

Aliskiren

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2
Q

Alpha 1 blockers

A

Prazosin and doxasosin

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3
Q

Combined alpha and beta blockers

A

Labetalol

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4
Q

Centrally acting drugs
Alpha 2 adrenoceptor agonists

A

Alpha adrenoceptor agonists ( clonidine and alpha methyldopa)

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5
Q

Vasodilators

A

Hydralazine

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6
Q

Endothelin blockers

A

Bosentan

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7
Q

Dopamine agonists

A

Fenoldopam

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8
Q

From its side effects it is induce lupus erythematosus

A

Hydralazine

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9
Q

Significant baroreceptors homeostatic responses so must be combined with diuretics and beta blockers

A

Hydralazine and minoxidil

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10
Q

Drug that is k channel opener that hyperpolarizes and relaxes vascular smooth muscle

A

Minoxidil

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11
Q

Now it is used to prevent hair loss

A

Minoxidil

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12
Q

From its side effects is hirsutism (hypertrichosis)

A

Minoxidil

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13
Q

Drug that is orally active nonselective blocker of ETA and ETB receptors

A

Bosentan

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14
Q

It is selective ETA blocker

A

Ambrisentan

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15
Q

Drugs used in pregnancy

A

Labetalol
Alpha methyldopa
Hydralazine

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16
Q

Drugs used in hypertension emergencies

A

Labetalol
Na nitroprusside
Fenoldopam

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17
Q

Used in hypertension with benign prostatic hyperplasia

A

Prazosin

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18
Q

From its characteristics is there is no reflex tachycardia

A

Labetalol

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19
Q

It’s major limitation is that it has long half life

A

Labetalol

20
Q

From its side effects
Nightmares and mental depression

A

Alpha methyldopa

21
Q

From its side effects
Mild hyperprolactenemia and extrapyrimidal manifestation

A

Alpha methyldopa

22
Q

From its side effects
Positive coombs test
Auto immune hemolytic anemia
Auto immune hepatitis

A

Alpha methyldopa

23
Q

Used in hypertension complicated by renal disease

A

Clonidine

24
Q

Used in reducing anxiety accompanying opiate withdrawal or surgical operations

A

Clonidine

25
Q

Sudden withdrawal of the drug can lead to rebound hypertension

A

Clonidine

26
Q

Cause salt and water retention so it is usually combined with diuretics

A

Clonidine

27
Q

Cause sedation and dry mouth

A

Clonidine

28
Q

Is a thiazide drugs but has no diuretics effects

A

Diazoxide

29
Q

Used in acute HF and it is sensitive to light

A

Na nitroprusside

30
Q

It is the main subtype in smooth muscle

A

ETA

31
Q

Used in treatment of primary pulmonary hypertension

A

Bosentan and ambrisentan

32
Q

It release nitric oxide from endothelial cells

A

Hydralazine

33
Q

It is a direct aretriodilator by opening k channel

A

Diazoxide

34
Q

It liberates nitric oxide

A

Na nitroprusside

35
Q

Given in emergency hypertension and acute heart failure

A

Na nitroprusside

36
Q

Toxicity of na nitroprusside can be reduced by

A

Sodium thiosulfate or hydroxylamine vit b 12

37
Q

Stimulate peripheral dopamine D1 receptors in renal and mesenteric arteries

A

Fenoldopam

38
Q

Used as rapid acting vasodilators to treat emergency hypertension

A

Fenoldopam

39
Q

In patients with pulmonary hypertension and Coronary artery disease which of the following is elevated

A

Endothelin -1

40
Q

Drug used in treatment of pulmonary hypertension

A

Bosentan and ambrisentan

41
Q

It inhibits renin activity and RAAS

A

Aliskiren

42
Q

Treatment of hyperreninemic hypertension

A

Aliskiren

43
Q

Alpha one blockers

A

Prazosin

44
Q

Block post synaptic alpha 1 adrenergic receptors leading to arterial and venous vasodilation

A

Prazoy

45
Q

From its side effects is orthostatic hypotension more with first dose

A

Prazosin

46
Q

Night mares
Sedation
Mental depression
Mild hyperprolactinemia
Positive coombs test are symptoms of which drug

A

Alpha methyldopa

47
Q

Is a central alpha 2 agonist

A

Clonidine

CVS pharmacology (7 decks)

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