Anticoagulant

Question 1

It is a polysaccharide present in mast cells and carry negative charge

Answer 1

Heparin

Question 2

Has a high molecular weight 30000 Dalton

Answer 2

Heparin

Question 3

Drug that can’t be taken orally

Answer 3

Heparin

Question 4

Can’t cross BBB and Placenta

Answer 4

Heparin

Question 5

Rapid onset and short duration (60 min)

Answer 5

Heparin

Question 6

Used in emergency

Answer 6

Heparin

Question 7

Drug that activate antithrombin 3

Answer 7

Heparin

Question 8

Drugs that inhibit clot factor 10

Answer 8

Heparin
Fondaparinux
Rivaroxaban

Question 9

It is an oral inhibitor of factor 10

Answer 9

Rivaroxaban

Question 10

Antidote of heparin is …

Answer 10

Protamine sulfate

Question 11

For control of therapy it should be kept 2-3times of it’s normal value

Answer 11

Heparin
Warfarin

Question 12

Bleeding, induced thrombocytopenia, hematoma, osteoporosis and alopecia are adverse effects of which drug ?

Answer 12

Heparin

Question 13

Has low molecular weight

Answer 13

Enoxaparin

Question 14

Has more specific anti factor 10 activity

Answer 14

Enoxaparin

Question 15

Has low non specific binding to plasma proteins

Answer 15

Enoxaparin

Question 16

High bioavailability after s.c. injection

Answer 16

Enoxaparin

Question 17

Long half life given only once

Answer 17

Enoxaparin

Question 18

Thrombocytopenia is less common when the patient take this drug

Answer 18

Enoxaparin

Question 19

Low risk of bleeding

Answer 19

Enoxaparin

Question 20

Aptt essential lab monitoring

Answer 20

Unfractionated heparin

Question 21

Extent inhibitor of.factor 10
Lab monitoring may be unnecessary

Answer 21

Enoxaparin

Question 22

Synthesic pentsaccharide drug

Answer 22

Fondaparinux

Question 23

It is a selective inhibitor of factor 10

Answer 23

Fondaparinux

Question 24

Given by S.C. injection once daily

Answer 24

Fondaparinux

Question 25

It is an oral inhibitor of factor 10

Answer 25

Rivaroxaban

Question 26

Oral drug that inhibit factor 2

Answer 26

Direct thrombin inhibitors
( Dabigatran)

Question 27

Used in treatment of heparin induced thrombocytopenia

Answer 27

Direct thrombin inhibitors ( dabigatran)

Question 28

Drug that has good bioavailability (100%)

Answer 28

Warfarin

Question 29

It is highly bound to the plasma proteins

Answer 29

Warfarin

Question 30

It is biotransformed by hepatic CYP450

Answer 30

Warfarin

Question 31

Drug that monitored by Prothrombin time and international normalized ratio

Answer 31

Warfarin

Question 32

Antidote of warfarin is

Answer 32

Vitamin K1

Question 33

It is an inhibitor of vitamin k .. reductase

Answer 33

Warfarin

Question 34

Drug monitored by activated partial thromboplastin time (APTT)

Answer 34

Heparin

Question 35

It is an anticoagulant in vivo and vitro

Answer 35

Heparin

Question 36

It is an anticoagulant in vivo only

Answer 36

Warfarin

Question 37

It is a plasminogen activator and fibrin selective drugs

Answer 37

Alteplase

Question 38

The following uses are for which drug
Acute coronary syndrome
Pulmonary embolism
Arterial thrombosis

Answer 38

Alteplase ( fibrinolytic drugs)

Question 39

From side effects of fibrinolytic is systemic bleeding
What should we give the patient to antagonize this adverse effect,

Answer 39

Antagonized by
Aminocaproic acid and tranexamic