Anti Hyperlipidemic Drug2 Flashcards
Fibric acid derivatives (fibrates) are
Gemfibrozil
Fenofibrate
Ciprofibrate
Drugs that can lower triglycerides level and in some patients LDL as well
Fibric acid derivatives
Gemfibrozil
Fenofibrate
Ciprofibrate
One of the following is completely absorbed after oral administration and its absorption is improved when taken with food
Gemfibrozil
It is from fibric acid derivatives and it is a prodrug that is hydrolyzed completely in intestine
Fenofibrate
From fibric acid derivatives and has very long half life of more than 2 days
Ciprofibrate
Agonist for peroxisome proliferator activated receptor alpha
Fibrates
Decrease expression of APO -CIII which inhibit lipase activity
Fibrates
Increase expression of protein APO A1 &APO A2 so inc HDL conc.
Fibrates
Which one from the following is more effective than gemfibrozil in lowering triacylglyceride levels
Fenofibrate
Uses of fibrates
Hypertriglyceridemia
Mixed hyperlipidemia in combination with other drugs
Mild gastrointestinal disturbances ( nausea, dyspepsia and diarrhea) is the most common adverse effects of …
Fibrates
Adverse effects of fibrates are
Mild gastrointestinal disturbances
Gall stones
Myopathy
Myosotis
Hypokalemia
Arrhythmias
Risk of myopathy and rhabdomyolysis increases when gemfibrozil is given with …
Statins
Fibrates potentiate the action of oral anticoagulant and oral antidiabetic
Contraindications of fibrates
Pregnancy and lactation
Severe hepatic or renal dysfunction
Gemfibrozil should not be combined with statins
Bile acid binding resins ( sequestrants)
Colestipol
Cholestyramine
Colesevelam
Useful only in increase LDL
Bile acid binding resins
Colestipol
Cholestyramine
Colesevelam
Uses of bile acid binding resins
Used in primary hypercholesterolemia
When statins are contraindicated and inadequate response to statins
Git upset especially constipation
Bile acid binding resins
Colestipol
Cholestyramine
Colesevelam
Decrease absorption of fat soluble vitamins at high doses
Bile acid binding resins
Form insoluble complex with other drugs
Colestipol
Colesevelam
Cholestyramine
Bile acid binding resins drug interactions are
Dec absorption of digitalis, thiazide, warfarin,
Tetracycline, aspirin, pravastatin and fluvastatin
A drug doesn’t bind digoxin, warfarin, reductase inhibitors
Colesvelam
Cholesterol absorption inhibitors
Ezetimibe
Selectively inhibits absorption of dietary and biliary cholesterol in the small intestine
Ezetimibe
Causes decrease hepatic cholesterol
Ezetimibe
Used as an adjuvant to statins therapy or in statin intolerant patients
Ezetimibe
Metabolized in the small intestine and liver with subsequent biliary and renal excretion
Ezetimibe
Adverse effects of Ezetimibe
Diarrhoea
Abdominal pain
Headache
Fatigue
Contraindications of Ezetimibe
Contraindicated in moderate to severe hepatic insufficiency
PCSK9 inhibitors are
Evolocumab
Alirocumab
Side effects of evolocumab and alirocumab (PCSK9 INHIBITORS)
Injection site reaction
Flu like symptoms
Neurocognitive problems
Inhibit VLDL and triacylglyceride synthesis in liver
Omega 3 fatty acids
Adverse effects of omega 3 fatty acids
Git disturbances
Fish after taste with fish derived omega 3
Increase risk of bleeding
Which one of fibrates can be safely given with statin
Fenofibrate
Cause small increase in LDL and HDL
Pufas ( omega 3 fatty acids)
