Antihyperlipidemic Therapies

Question 1

PUFAs

Answer 1

Omega 3 fatty acids: ALA, EPA, DHA: Treamtment for Triglycerides

Question 2

HMGCoA Reductase Inhibitor Mechanism

Answer 2

Blocks HMGCoA R. and stops Acetyl CoA from becoming cholesterol, upregulates liver LDL receptors and and decreases LDL in blood

Question 3

HMGCoA Reductase Inhibitor Drugs

Answer 3

Atorvastatin(Lipitor), Rosuvastatin(Crestor), Fluvastatin(Lescol), Lovastatin(Mevacor), Pravastatin(Pravachol), Simvastatin(Zocor)

Question 4

HMGCoA Reductase Inhibitor Side Effects

Answer 4

Rhabdomyolysis, contraindicated in pregnancy

Question 5

Simvastatin(Zocor)

Answer 5

Statin, CYP3A4, Liver

Question 6

Atorvastatin(Lipitor)

Answer 6

Statin, CYP3A4, Liver

Question 7

Rosuvastatin(Crestor)

Answer 7

Statin, CYP2C9/19, Liver

Question 8

Fluvastatin(Lescol)

Answer 8

Statin, CYP2C9, Liver

Question 9

Lovastatin(Mevacor)

Answer 9

Statin, CYP3A4, Liver

Question 10

Pravastatin(Pravachol)

Answer 10

Statin, Non-CYP, 50/50 Liver and Renal

Question 11

Bile Acid Sequestrants Mechanism

Answer 11

Bind bile acids in the intestine causing them to be excreted. Consequently the liver turns more cholesterol into bile acids.

Question 12

Bile Acid Sequestrant Drugs

Answer 12

Cholestyramine(Questran), Colestipol(Colestid), Colesevelam(WelChol)

Question 13

Bile Acid Sequestrant Side Effects

Answer 13

Dietary absorption

Question 14

NIcotinic Acid(Niacin)

Answer 14

Thirdline for lowering LDL-C but MOST EFFECTIVE ON MARKET for raising HDL

Question 15

NIcotinic Acid(Niacin) Side Effects

Answer 15

Hot flashes, nausea, contraindicated in pregnancy

Question 16

Niaspan

Answer 16

programmed release formula of Nicotinic Acid

Question 17

Fibric Acid Derivatives

Answer 17

First line therapy for lowering triglycerides

Question 18

Fibric Acid Derivative Drugs

Answer 18

Gemfibrozil(Lopid), Fenofibrate(Tricor)

Question 19

Gemfibrozil(Lopid)

Answer 19

Fibric Acid Derivative, lowers TGs, Lowers LDL, Raises HDL, avoid in patients with Liver and Renal problems

Question 20

Fenofibrate(Tricor)

Answer 20

Indicated only for severe hypertriglyceridema, used in conjunction with Statins, BUT MAY INCREASE RABDO causes GI upset & rashes

Question 21

Ezetimibe(Zetia)

Answer 21

Inhibition of cholesterol absorption, used in combination with statins, side effects include Rhabdo

Question 22

Mipomersen(Kynamro)

Answer 22

mRNA antisense mismatch for apolipoprotein B

Question 23

PCSK9 Inhibitors

Answer 23

PCSK9 is upregulated in the presence of Statins increasing serum LDL