Antihyperlipidemic Therapies Flashcards
PUFAs
Omega 3 fatty acids: ALA, EPA, DHA: Treamtment for Triglycerides
HMGCoA Reductase Inhibitor Mechanism
Blocks HMGCoA R. and stops Acetyl CoA from becoming cholesterol, upregulates liver LDL receptors and and decreases LDL in blood
HMGCoA Reductase Inhibitor Drugs
Atorvastatin(Lipitor), Rosuvastatin(Crestor), Fluvastatin(Lescol), Lovastatin(Mevacor), Pravastatin(Pravachol), Simvastatin(Zocor)
HMGCoA Reductase Inhibitor Side Effects
Rhabdomyolysis, contraindicated in pregnancy
Simvastatin(Zocor)
Statin, CYP3A4, Liver
Atorvastatin(Lipitor)
Statin, CYP3A4, Liver
Rosuvastatin(Crestor)
Statin, CYP2C9/19, Liver
Fluvastatin(Lescol)
Statin, CYP2C9, Liver
Lovastatin(Mevacor)
Statin, CYP3A4, Liver
Pravastatin(Pravachol)
Statin, Non-CYP, 50/50 Liver and Renal
Bile Acid Sequestrants Mechanism
Bind bile acids in the intestine causing them to be excreted. Consequently the liver turns more cholesterol into bile acids.
Bile Acid Sequestrant Drugs
Cholestyramine(Questran), Colestipol(Colestid), Colesevelam(WelChol)
Bile Acid Sequestrant Side Effects
Dietary absorption
NIcotinic Acid(Niacin)
Thirdline for lowering LDL-C but MOST EFFECTIVE ON MARKET for raising HDL
NIcotinic Acid(Niacin) Side Effects
Hot flashes, nausea, contraindicated in pregnancy
Niaspan
programmed release formula of Nicotinic Acid
Fibric Acid Derivatives
First line therapy for lowering triglycerides
Fibric Acid Derivative Drugs
Gemfibrozil(Lopid), Fenofibrate(Tricor)
Gemfibrozil(Lopid)
Fibric Acid Derivative, lowers TGs, Lowers LDL, Raises HDL, avoid in patients with Liver and Renal problems
Fenofibrate(Tricor)
Indicated only for severe hypertriglyceridema, used in conjunction with Statins, BUT MAY INCREASE RABDO causes GI upset & rashes
Ezetimibe(Zetia)
Inhibition of cholesterol absorption, used in combination with statins, side effects include Rhabdo
Mipomersen(Kynamro)
mRNA antisense mismatch for apolipoprotein B
PCSK9 Inhibitors
PCSK9 is upregulated in the presence of Statins increasing serum LDL
