Anti-thrombotic Drugs

Question 1

Aspirin

Answer 1

Class 1, COX1 inhibitor

Use for unstable angina, MI, following TIA

Question 2

Clopidogrel (Plavix)

Answer 2

Class 2, P2Y12 (ADP) inhibitor
use when stenting, high risk ACS
give in combination with aspirin

Question 3

Aspirin Side Effects

Answer 3

Side effects include bleeding when given with other anticoags, stomach problems

Question 4

Clopidogrel Side Effects

Answer 4

bleeding (especially when combined with other platelet inhibitors), irreversible, 16% non-respondance rate

Question 5

Prasugrel (Effiant)

Answer 5

Class 2, P2Y12 (ADP) inhibitor
faster platelet inhibition with less drug
will eventually replace plavix

Question 6

Ticangelor

Answer 6

Class 2, P2Y12 (ADP) inhibitor

Faster than plavix

Question 7

Cangrelor

Answer 7

Class 2, P2Y12 (ADP) inhibitor

1/2 life of 3-5min

Question 8

Abciximab (ReoPro)

Answer 8

Class 3, GBIIb antagonist

use in unstable angina, MI, and PCI

Question 9

Eptifibatide (Integrilin)

Answer 9

Class 3, GBIIb antagonist

use in unstable angina, MI, and PCI

Question 10

Tirofiban (Aggrastat)

Answer 10

Class 3, GBIIb antagonist

use in unstable angina, MI, and PCI

Question 11

GBIIb antagonist side effects

Answer 11

bleeding

Question 12

Enoxaparin (Lovenox)

Answer 12

LMWH

Question 13

Dalteparin (Fragmin)

Answer 13

LMWH

Question 14

Trizaparin (Innohep)

Answer 14

LMWH

Question 15

Fondaparinux Sodium

Answer 15

Factor Xa inhibitor

Question 16

Warfarin

Answer 16

Vit K oxidation blocker, can be reversed in 15min with prothrombin complex concentrate

Question 17

Coumarins

Answer 17

Vit K antagonists

Question 18

Bivalirudin (Angiomax)

Answer 18

Direct Thrombin Inhibitor, no platelet activation, reversible, high specificity and potency

Question 19

Lepirudin (Refludin)

Answer 19

Direct Thrombin Inhibitor

Question 20

Argatroban

Answer 20

Direct Thrombin Inhibitor

Question 21

Dabigatran (Pradaxa)

Answer 21

Direct Thrombin Inhibitor with short 1/2 life