Angina Drugs

Question 1

Determinants of Myocardial Oxygen Demand

Answer 1

Wall stress, heart rate, contractility

Question 2

Nitrate Mechanism

Answer 2

Acts as NO. In low dose venodilation and high dose vasodilation, decreases preload, decrease wall tension, Increased O2 delivery

Question 3

Nitrate Administration

Answer 3

Sublingually to avoid first pass effect. Can be given acute or chronic

Question 4

Nitrate Side Effects

Answer 4

headache, hypotension, reflex tach, NO BENEFIT FOR MORTALITY

Question 5

B-blocker mechanism

Answer 5

block B-Adrenergic receptors decreasing sympathetic tone. Overall less O2 consumption and some perfusion, SHOW DECREASE IN MORTALITY increase

Question 6

B-blocker side effects

Answer 6

excessive bradycardia, bronchoconstriction, exacerbate diabetic control, use B1 selective for asthmatics

Question 7

Ca+2 blocker mechanism

Answer 7

coronary dilation, decreased afterload, SOME have cardiac depression

Question 8

Dihydropyridines

Answer 8

Ca+2 blockers only affecting coronary dilation

Question 9

Diltiazem, Verapamil

Answer 9

Ca+2 blockers with coronary dilation and cardiac depression

Question 10

Ca+2 blocker side effects

Answer 10

bradyarrhythmias, hypotension, ankle edema

Question 11

Ranolazine

Answer 11

blocks late phase inward Na+