Antihyperlipidemic Drugs Flashcards
HMG-CoA reductase inhibitors
-statin
-Statin drug MAO
inhibit rate limiting step in cholesterol biosynthesis
-statin drug use
hyperlipoproteinemia
hypercholestrolemia
hypertriglyceridemia
what do statin drugs do?
reduce LDL, cholesterols and TG
increase HDL
secondary prevention of heart disease
-statin drug side effects
myopathy
renal failure
increase ALT, AST
-statin contraindication
before 18 yrs
cholestyramine
bile acid sequestrates
cholestipol
bile acid sequestrates
cholesevelam
bile acid sequestrates
bile acid sequestrates MOA
Bind bile acid in GI and excrete in faeces
cause more cholesterol to make more bile
decrease LDL
Bile acid sequestrate not used …
not used in hypertriglyceridemia because increase in VLDL and TG
Bile acid sequestrate side effects
constipation
malabsorption of ADEK vitamins
malabsorption of digoxin, thiazide, warfarin
Cholestyramine use
pruritus due to biliary obstruction
Nicotinic acid MOA
inhibit VLDL synthesis. activates lipoprotein lipase
another name for nicotinic acid
niacin
Niacin side effects
flushing and pruritus (histamine release) hyperurecemia gastric irritation myopathies glucose intolerance
gemfibrozil, clofibrate, fenobibrate
fibric acid derivatives
Fibric acid derivative MOA
activate lipoprotein lipase to decrease VLDL, TG, LDL
Activate PPAR-a
Fibric acid derivative side effects
flu-like muscle aches
gallstone
allergic reaction
blood cell deficiencies
Cholesterol absorption inhibitor
ezetimibe
Ezetimibe MOA
Inhibit cholesterol absorption in small intestine
ezetimibe side effects
sinusitis, pharyngitis, headache, myalgia
ezetimibe used with
simvastatin
PCSK9 Inhibitors
Evolocumab
Alirocumab
PCSK9 inhibitors side effects
injection site rxn
increase ALT, AST
MSK pain
