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AUA CVS Pharm > Antihyperlipidemic Drugs > Flashcards

Antihyperlipidemic Drugs Flashcards

1
Q

HMG-CoA reductase inhibitors

A

-statin

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2
Q

-Statin drug MAO

A

inhibit rate limiting step in cholesterol biosynthesis

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3
Q

-statin drug use

A

hyperlipoproteinemia
hypercholestrolemia
hypertriglyceridemia

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4
Q

what do statin drugs do?

A

reduce LDL, cholesterols and TG
increase HDL
secondary prevention of heart disease

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5
Q

-statin drug side effects

A

myopathy
renal failure
increase ALT, AST

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6
Q

-statin contraindication

A

before 18 yrs

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7
Q

cholestyramine

A

bile acid sequestrates

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8
Q

cholestipol

A

bile acid sequestrates

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9
Q

cholesevelam

A

bile acid sequestrates

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10
Q

bile acid sequestrates MOA

A

Bind bile acid in GI and excrete in faeces
cause more cholesterol to make more bile
decrease LDL

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11
Q

Bile acid sequestrate not used …

A

not used in hypertriglyceridemia because increase in VLDL and TG

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12
Q

Bile acid sequestrate side effects

A

constipation
malabsorption of ADEK vitamins
malabsorption of digoxin, thiazide, warfarin

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13
Q

Cholestyramine use

A

pruritus due to biliary obstruction

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14
Q

Nicotinic acid MOA

A

inhibit VLDL synthesis. activates lipoprotein lipase

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15
Q

another name for nicotinic acid

A

niacin

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16
Q

Niacin side effects

A 
flushing and pruritus (histamine release)
hyperurecemia
gastric irritation
myopathies
glucose intolerance
17
Q

gemfibrozil, clofibrate, fenobibrate

A

fibric acid derivatives

18
Q

Fibric acid derivative MOA

A

activate lipoprotein lipase to decrease VLDL, TG, LDL

Activate PPAR-a

19
Q

Fibric acid derivative side effects

A

flu-like muscle aches
gallstone
allergic reaction
blood cell deficiencies

20
Q

Cholesterol absorption inhibitor

A

ezetimibe

21
Q

Ezetimibe MOA

A

Inhibit cholesterol absorption in small intestine

22
Q

ezetimibe side effects

A

sinusitis, pharyngitis, headache, myalgia

23
Q

ezetimibe used with

A

simvastatin

24
Q

PCSK9 Inhibitors

A

Evolocumab

Alirocumab

25
Q

PCSK9 inhibitors side effects

A

injection site rxn
increase ALT, AST
MSK pain

AUA CVS Pharm (5 decks)

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