Adrenoreceptor Agonist & Antagonist Flashcards
Phenylephrine
Alpha 1 agonist
Blocks tyrosine hydroxylase
Metyrosine
Blocks NE reuptake
cocaine
Increase NE release
amphetamine
Blocks NE storage in vesicles
Reserpine
a1 receptors
increase TPR/SVR
a2 receptors
inhibit neurotransmitter release
b1 receptors
increase HR and contractility
renin release
b2 receptors
bronchodilation
decrease TPR/SVR
D1 receptors
renal, mesenteric, coronary dilation
Epinephrine acts
on all receptors
low epinephrine concentration
beta receptor effects
high epinephrine concentration
great a1 effects
Norepinephrine does not act
on b2 receptors
Phenylephrine
a1 agonist
Drugs for hypo perfusion by acute MI
dopamine
norepinephrine
dobutamine
Dobutamine
b1 agonist
Isoproterenol
b1 and b2 agonist
Phenoxybenzamine
Irreversible
non selective alpha agonist
oral
Prazosin
selective a1 antagonist
Phentolamine
non selective alpha antagonist
phenoxybenzamine used for
pheochromocytoma
Propanolol
nonselective BB
Metoprolol
b1 selective BB
Carvedilol
nonselective BB + a1
Labetalol
nonselective BB + a1
Doxazosin only use
Hypertension
-zosin use
used for BPH