Anti-arrhythmic drugs Flashcards

1
Q

Quinidine

A

1a Na+ channel blocker

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2
Q

Procainamide

A

1a Na+ channel blocker

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3
Q

Disopyramide

A

1a Na+ channel blocker

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4
Q

1a sodium channel blockers MOA

A

decrease Vmax

increase APD

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5
Q

Quinidine MOA

A

Anticholinergic

alpha blocking: vasodilation & reflex tachycardia

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6
Q

Quinidine side effects

A

increase QT interval (tornadoes de pointes)
thrombocytopenia
cinchonism: tinnitus, hearing loss, GI upset, diplopia

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7
Q

Quinidine drug interaction

A

with antacids

increase quinidine absorption

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8
Q

Procainamide side effects

A

Agranulocytosis

SLE like syndrome

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9
Q

Disopyramide

A

most anticholinergic

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10
Q

Lidocaine
Tocainide
Mexiletine

A

1b Na+ channel blocker

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11
Q

1c Na+ channel blocker

A

Flecainide
propafenone
moricizine

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12
Q

1c Na+ channel blocker

A

Pro-arryhthmetic

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13
Q

BB use

A

prophylaxis post MI

SVT treatment

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14
Q

K+ channel blocker

A

increase APD

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15
Q

K+ channel blocker

A
Amiodarone
Ibutilide
Dofetilide
Dronaderone
Sotalol
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16
Q

Ibutilide

Dofetilide

A

Selectively block outward potassium

increase QT interval

17
Q

Ibutilide & Dofetilide pharm use

A

cardio version of afib and flutter

18
Q

Amiodarone

A

mimics all classes

19
Q

Amiodarone side effects

A
pulmonary fibrosis
hepatotoxicity
smurf skin
hypo- & hyper- thyroidism
torsades de pointes
20
Q

Sotalol

A

BB and K+ channel blocker

21
Q

Sotalol use

A

treat life threatening V arrhythmia

22
Q

Sotalol side effects

A

headache
depression
impotence
*asthmatic

23
Q

Verapamil & Diltiazem

A

Ca2+ channel blocker

24
Q

Ca2+ channel blocker

A

decrease slope of phase 4

25
Q

Verapamil & Diltiazem use

A

to treat PSVT due to AV node reentry

26
Q

Verapamil & Diltiazem C/I

A

WPW

27
Q

Adenosine use

A

treat PSVT

28
Q

Adenosine antagonist

A

Theophylline

29
Q

Torsades de pointes management

A

K+ & magnesium sulphate