Anti-arrhythmic drugs Flashcards

Question 1

Q

Quinidine

Answer

A

1a Na+ channel blocker

Question 2

Q

Procainamide

Answer

A

1a Na+ channel blocker

Question 3

Q

Disopyramide

Answer

A

1a Na+ channel blocker

Question 4

Q

1a sodium channel blockers MOA

Answer

A

decrease Vmax

increase APD

Question 5

Q

Quinidine MOA

Answer

A

Anticholinergic

alpha blocking: vasodilation & reflex tachycardia

Question 6

Q

Quinidine side effects

Answer

A

increase QT interval (tornadoes de pointes)
thrombocytopenia
cinchonism: tinnitus, hearing loss, GI upset, diplopia

Question 7

Q

Quinidine drug interaction

Answer

A

with antacids

increase quinidine absorption

Question 8

Q

Procainamide side effects

Answer

A

Agranulocytosis

SLE like syndrome

Question 9

Q

Disopyramide

Answer

A

most anticholinergic

Question 10

Q

Lidocaine
Tocainide
Mexiletine

Answer

A

1b Na+ channel blocker

Question 11

Q

1c Na+ channel blocker

Answer

A

Flecainide
propafenone
moricizine

Question 12

Q

1c Na+ channel blocker

Answer

A

Pro-arryhthmetic

Question 13

Q

BB use

Answer

A

prophylaxis post MI

SVT treatment

Question 14

Q

K+ channel blocker

Answer

A

increase APD

Question 15

Q

K+ channel blocker

Answer

A

Amiodarone
Ibutilide
Dofetilide
Dronaderone
Sotalol

Question 16

Q

Ibutilide

Dofetilide

Answer

A

Selectively block outward potassium

increase QT interval

Question 17

Q

Ibutilide & Dofetilide pharm use

Answer

A

cardio version of afib and flutter

Question 18

Q

Amiodarone

Answer

A

mimics all classes

Question 19

Q

Amiodarone side effects

Answer

A

pulmonary fibrosis
hepatotoxicity
smurf skin
hypo- &amp; hyper- thyroidism
torsades de pointes

Question 20

Q

Sotalol

Answer

A

BB and K+ channel blocker

Question 21

Q

Sotalol use

Answer

A

treat life threatening V arrhythmia

Question 22

Q

Sotalol side effects

Answer

A

headache
depression
impotence
*asthmatic

Question 23

Q

Verapamil & Diltiazem

Answer

A

Ca2+ channel blocker

Question 24

Q

Ca2+ channel blocker

Answer

A

decrease slope of phase 4

Question 25

Q

Verapamil & Diltiazem use

Answer

A

to treat PSVT due to AV node reentry

Question 26

Q

Verapamil & Diltiazem C/I

Question 27

Q

Adenosine use

Answer

A

treat PSVT

Question 28

Q

Adenosine antagonist

Answer

A

Theophylline

Question 29

Q

Torsades de pointes management

Answer

A

K+ & magnesium sulphate