antihistimines

Question 1

what other properties to sedative anthistimines have?

Answer 1

ANTIMUSCARINIC

Question 2

which patients should antihistimes be cautioned in?

Answer 2

epilepsy
liver disease - risk of coma if they are sedating, should be avoided
children and elderly more prone to side effects

Question 3

side effects of antihistimines?

Answer 3

• drowsiness
• headache
• need to avoid excess alccohol
• dry mouth
• blurred vision
  GI disturbances
  urinary retention

Question 4

what is cystic fibrosis?

Answer 4

genetic disorder - affecting the lungs, liver, pancreas, intenstine and reprodutive organs

Question 5

what is used in cystic fibrosis?

Answer 5

immunosuppresants
colysteramine
creon
carbacistine

Question 6

what are the symptoms of CF

Answer 6

• pulomonary disease
• recurrent infection
• production viscous sputum
• malabsorption due to pancreatic insufficency - oesteoprosis

Question 7

aim of treatment (cystic fibrosis) ?

Answer 7

optimize lung function (inhaltion)
hydration and nutrients 
loosen mucus
airway clearance
regular excersize to improve fitness

need to see patient every 3 months

Question 8

first line for CF?

Answer 8

dornase alfa or DPI if this not tolerated

Question 9

when should mucolytics be stopped in CF patients?

Answer 9

If no benifit after 4 week trial.

Question 10

which patients should mucolytics be cautioned in?

Answer 10

those who have peptic ulceration, as may disrupt gastric mucosal barrier

Question 11

Caustions of LABA and SABA?

Answer 11

arrhythmias

• hypokaleimia
• QT prolongation

Question 12

active ingredient in seritide?

Answer 12

salmetarol (green)

Question 13

laba interactions?

Answer 13

hypokalemia worsened by other potassium lowering drugs e.g. loop duiretics

Question 14

LABA examples ?

Answer 14

oxis turbohaler, fostair, onbrez, breezhaler, serevent

Question 15

antimuscarinic cautions?

Answer 15

prostatic hyperplasia

Question 16

antimuscarinic se?

Answer 16

dry mouth, cough, headache

Question 17

Flixitide active ingredients?

Answer 17

Fluticasone

Question 18

SE if ICS?

Answer 18

candidais of the mouth, throat irritation, hoarsness

Question 19

LTRA cautions?

Answer 19

elderly

Question 20

LTRA SE

Answer 20

• abdominal pain
• Churg strauss syndrome
• hepatoxicity

Question 21

LTRA egs?

Answer 21

zafirlukast

montelukast

Question 22

symptoms of liver failure?

Answer 22

jaundice, itching, dark urine, abdominal pain