antihistimines Flashcards
what other properties to sedative anthistimines have?
ANTIMUSCARINIC
which patients should antihistimes be cautioned in?
epilepsy
liver disease - risk of coma if they are sedating, should be avoided
children and elderly more prone to side effects
side effects of antihistimines?
- drowsiness
- headache
- need to avoid excess alccohol
- dry mouth
- blurred vision
GI disturbances
urinary retention
what is cystic fibrosis?
genetic disorder - affecting the lungs, liver, pancreas, intenstine and reprodutive organs
what is used in cystic fibrosis?
immunosuppresants
colysteramine
creon
carbacistine
what are the symptoms of CF
- pulomonary disease
- recurrent infection
- production viscous sputum
- malabsorption due to pancreatic insufficency - oesteoprosis
aim of treatment (cystic fibrosis) ?
optimize lung function (inhaltion) hydration and nutrients loosen mucus airway clearance regular excersize to improve fitness
need to see patient every 3 months
first line for CF?
dornase alfa or DPI if this not tolerated
when should mucolytics be stopped in CF patients?
If no benifit after 4 week trial.
which patients should mucolytics be cautioned in?
those who have peptic ulceration, as may disrupt gastric mucosal barrier
Caustions of LABA and SABA?
arrhythmias
- hypokaleimia
- QT prolongation
active ingredient in seritide?
salmetarol (green)
laba interactions?
hypokalemia worsened by other potassium lowering drugs e.g. loop duiretics
LABA examples ?
oxis turbohaler, fostair, onbrez, breezhaler, serevent
antimuscarinic cautions?
prostatic hyperplasia
antimuscarinic se?
dry mouth, cough, headache
Flixitide active ingredients?
Fluticasone
SE if ICS?
candidais of the mouth, throat irritation, hoarsness
LTRA cautions?
elderly
LTRA SE
- abdominal pain
- Churg strauss syndrome
- hepatoxicity
LTRA egs?
zafirlukast
montelukast
symptoms of liver failure?
jaundice, itching, dark urine, abdominal pain
