Antihistaminic substances Flashcards
Antazoline Hydrochloride
H1 Blocker
Less active and less local irritant
in ophtalmology
Diphenhydramine hydrochloride
H1 Blocker
More active, effects occur quickly and action takes longer
Sedative + antiemeticAtropine like acyion in combating the irritation in the upper respiratory tract
Mepyraminemaleate
H1 Blocker
weak sedative and local anesthesic
antistaminic action time shorter
Chlorphenilamine
sedative effact weaker thatn diphen…
Promethazine Chloride
H1 Blocker
Intermediate bet chlor.. and diphen..
Antiemetic (best for motion sickness)
Antihistaminic, antiallergic, bechic
Potencialliser pf depresors, pshycoplegic and antiparkinsonian
In acute laminitis, dermatitis, anaphilactic accidents
H2 blockers
- Burimamide
- Metiamide
- Cimetidine and Ranitidine
- competitive antagonistb of histamines
- no serious side effects
- in duodenal ulcers
Sodium Cromoglycate
Inhibitors of histamine
No antihistaminic effect nor smooth mucle relaxant
Effect mediated through pulmonary mastocytes
Ca not entering into the mastocytes is not actuvated as a result of exposure to antigen
5 - HT
Inhibitors of histamine
Also known as serotonine or vasotonin
Located in the argetaffin cells of the GI tract
Reserpine
Inhibitors of histamine
Liberating activity of noradrenaline and stored 5HT
Deplation of 5HT -> reserpine induced depresion
5Ht action = contraction of most smooth muscles in blood vessels but dilatates arterioles
5Ht antagonists
Inhibitors of histamine
Control of anaphylaxes in cows
members f the ergotamine group or simple derivarives of lysergic acid
Cyproheptadine
Inhibitors of histamine
Antagonizes competitive histamine and serotonine
Trimeprazine
Inhibitors of histamine
in controlling thepruritus in dogs skins disesases
