Antihelmintic Drugs Flashcards
Vermifuges definition
Paralyze the worm
Vermicides definition
Kill parasitic worms
A nematode is a
Round worm
A cestode is a
Tape worm
A trematode is a
Flat worms
What are filaria?
Worms in lymphatics or under skin
What is cysticercosis?
Tissue infection after exposure to eggs of Taenia solium ➡️cysts in brain
What is echinococcus?
Tissue infection with dog tapeworm ➡️cysts in liver/lung
Trematodes can be found in which organs? (5)
Blood Liver Pancreas Lung Intestinal
3 Benzimdazoles
Albendazole
Mebendazole
Thiabendazole
Spectrum of benzimdazoles
Broad spectrum Anti-nematode & anti-cestode
Bezimidazoles are the drug of choice for which 3 parasites?
Ascaris
Trichuris
Trichinella
Mechanism of action of benzimidazoles? Inhibit which enzyme?
Polymerization of tubulin into microtubules; prevents growth; inhibit mitochondrial fumarate reductase
Drug of choice for neurocysticerosis (pork tapeworm) & hydatid
Albendazole
Drug of choice for trichuris, ascaris, pinworm?
Mebendazole
Drug of choice for Strongyloidal infections and Onchocerciasis, scabies, lice?
Ivermectin
Thiabendazole is a chelator of
Iron
Mazzotti’s reaction occurs with what 2 anti-parasitic drugs?
diethylcarbamazine & Ivermectin
Drug of choice for filariasis and Loa loa?
diethylcarbamazine
Drug of choice for shistosomes, Taenia (tape worms)?
Praziquantel
Mechanism of praziquantel?
Disrupts covering membrane of shistocytes = rapid Calcium influx (tetanus)
