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Antimicrobials > Antihelmintic Drugs > Flashcards

Antihelmintic Drugs Flashcards

1
Q

Vermifuges definition

A

Paralyze the worm

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2
Q

Vermicides definition

A

Kill parasitic worms

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3
Q

A nematode is a

A

Round worm

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4
Q

A cestode is a

A

Tape worm

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5
Q

A trematode is a

A

Flat worms

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6
Q

What are filaria?

A

Worms in lymphatics or under skin

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7
Q

What is cysticercosis?

A

Tissue infection after exposure to eggs of Taenia solium ➡️cysts in brain

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8
Q

What is echinococcus?

A

Tissue infection with dog tapeworm ➡️cysts in liver/lung

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9
Q

Trematodes can be found in which organs? (5)

A 
Blood
Liver
Pancreas
Lung
Intestinal
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10
Q

3 Benzimdazoles

A

Albendazole
Mebendazole
Thiabendazole

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11
Q

Spectrum of benzimdazoles

A

Broad spectrum Anti-nematode & anti-cestode

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12
Q

Bezimidazoles are the drug of choice for which 3 parasites?

A

Ascaris
Trichuris
Trichinella

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13
Q

Mechanism of action of benzimidazoles? Inhibit which enzyme?

A

Polymerization of tubulin into microtubules; prevents growth; inhibit mitochondrial fumarate reductase

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14
Q

Drug of choice for neurocysticerosis (pork tapeworm) & hydatid

A

Albendazole

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15
Q

Drug of choice for trichuris, ascaris, pinworm?

A

Mebendazole

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16
Q

Drug of choice for Strongyloidal infections and Onchocerciasis, scabies, lice?

A

Ivermectin

17
Q

Thiabendazole is a chelator of

A

Iron

18
Q

Mazzotti’s reaction occurs with what 2 anti-parasitic drugs?

A

diethylcarbamazine & Ivermectin

19
Q

Drug of choice for filariasis and Loa loa?

A

diethylcarbamazine

20
Q

Drug of choice for shistosomes, Taenia (tape worms)?

A

Praziquantel

21
Q

Mechanism of praziquantel?

A

Disrupts covering membrane of shistocytes = rapid Calcium influx (tetanus)

Antimicrobials (6 decks)

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