Antigens and pathogens Flashcards
antigens
molecules that interact with the cells of the immune system, they are capable of inducing an immune response
what are the two types of antigens
self and non-self
self antigens
antigens located on the surface of cells that originate from the organism
what is the purpose of self-antigens
marks the cells of the organism as self which prevents the immune system eliciting a response against the, important self antigens can take the form of MHC proteins
MHC proteins stand
major histocompatiubilty complex proteins
what are MHC I proteins
proteins expressed on all nucleated cells (i.e. not red blood cells)
what are MHC II proteins
proteins found on specialised cells of the immune system
how are MHC proteins formed
each MHC marker contains a degraded peptide (part of a degraded protein) that was bound to it inside of the cell. The MHC marker is then moved to the plasma membrane abd presents it peptide on the surface
self vs non-self
self means cells and molecul;es that make up ur own body, non-self is anything else
non-self antigens
marks a cell/pathogen as forgein to the organism, proteins on the cells surface will induce an immune response
autoimmune disease
when the cells of the immune system incorrectly identify self antigens as non-self antigens and illicit an immune response
what determines the blood type of an individual
the surface proteins found on their red blood cellst
type o blood antibodies and antigens on red blood cells
antibodies; anti A and anti B, antigens: none
type A blood antibodies and antigens on red blood cells
antibodies; anti b, antigen; antigen a
type B blood antibodies and antigens on red blood cells
antibodies; anti a antigen; antigen b
type AB blood antibodies and antigens on red blood cells
antibodies; none antigens; antigen A and antigen B
why can a person with A type blood donate to a person with B type blood and vis versa and why cant o type blood recieve AB A and B
the B/A antigens on the blood surface will be recognised as non-self and will trigger as immune response due to anti b/anti a antibodies
why can o group dopnate tpo anybody
there are no markers on their red blood cells top recognise as non-self
can type AB recieve anthing
yes as they have no antibodiesd that will react with the A/B antigensd
what are the cellular pathogens
bacteria, fungi and protozoa - all unicellular, ticks and worms - all multicellular
what are the non-cellular pathogens
virus and prions
what is a pathogen
the causative agent of an infectiopus disease
structure of bacteria
prokayotic, contain a cell wall, use binary fission to reproduce, contain flagella to move
why do bacteria infect
to gain nutrients from the host
when food supply runs low, bacteria form…
spores which can survive non-ideal conditions and varying temps
what makes bacteria toxic/pathogenic
when they release exotoxins and/or endotoxins and/or enzymes which either affect the functioning or cells or kills the cells
exooxins
toxic compound released by bacteria into their environment and carried through the blood stream, more harmful
endotoxins
toxic compound apart of the exterior wall of gram negative bacteria, is released when bacteria dies, lees harmful as contained within a cell until that cell dies
gram negative bacteria
contain a lipid coat so doesnt release toxins but when it dies, toxins are released
how bacteria can be transmitted
contaminated food/water, touching, droplets in the air
bacterial infection treatment
antibiotics - can be determined which antibiotic will be effective against the specific type of bacteria through sensitivity testing
how do antibiotics work
interfering with the making of the bacterial cell wall, some stop production of important chemicals/ proteins needed by the bacteria by interrupting translation, some interefere with the genetic material of the bacteria, causing it to stop dividing