Antigen

Question 1

Immunogen

Answer 1

Substances that generate immune response

Question 2

Antigen

Answer 2

Any substance that reacts with T or B cells

Question 3

Relationship between antigens and immunogens

Answer 3

All immunogens are antigens, but not all antigens are immunogens

Question 4

Alloantigen

Answer 4

Antigen determinants found on a molecular structure of some species members, but not on corresponding molecular structure of other members of species

Question 5

Mitogen

Answer 5

Substance that induces multiple clones of cells

Binds to exterior of all T cells

Question 6

Superantigens

Answer 6

Bind to outside of normal T cell binding area, causing activation of multiple T cells (dependent on variable region)

Question 7

Common superantigens

Answer 7

Staphylococcal enterotoxins

Toxic shock syndrome toxin 1

Question 8

Haptens

Answer 8

Small molecules that can’t induce immune response on own; must be bound to carrier molecule

Question 9

What antigen conformations B cells recognize

Answer 9

Primary (amino acid sequence) and tertiary (folded protein)

Question 10

What antigen conformations T cells recognize

Answer 10

Primary only (amino acid sequence)

Question 11

Adjuvant

Answer 11

Prolongs antigen persistance
Enhances co-stimulatory signal
Stimulates lymphocytes nonspecifically

Question 12

Epitope

Answer 12

Small site on antigen which is recognized by antibody

Question 13

Antigenic determinant

Answer 13

Cluster of epitopes on surface of antigen

Question 14

Interaction with antigen: B cells

Answer 14

Binary complex of membrane antibody and antigen

Question 15

Interaction with antigen: T cells

Answer 15

Ternary complex of T cell receptor, antigen, and MHC molecule