Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Year II Pharmacology Term 5 > Antifungals > Flashcards

Antifungals Flashcards

1
Q

Fungal Cell wall compoyent

A

Mannoprotins
Glucan
Chitin
Polyschridea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Fungal cell wall

A

Ergosterol (cholesterol in humans)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Azoles - General

MOA
SE
Metabolism

A

MOA
Inhibit rate limiting step in ergosterol synthesis
CYP 450 inhibit

SE

  • GI upset
  • Rash
  • Hepatitis
  • Rash
  • H/A

Metabolism

  • Fluconazole: renal
  • Vori & itra: hepatic (cyp 450)
  • Posa: hepatic (glucuronidation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Fluconazole

Formulation
Use
Resistance

A

Benefits

  • IV or oral (good oral absorbtion & CNS)
  • Fewest drug interactions
  • CNS penetatrion

Use

  • Yeast (candidiasis & cryptococcus neoforms)
  • No activity aainst molds

Resisatnt

  • C. krusei
  • T. glbrata
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Itraconazole

Downsides
Activity
SE

A

Downside

  • Poor GI and CNS penetration
  • Most drug interaction

Activity

  • First systemic therapy
  • Most yeast, molds & diamorphics
  • Drug of choice for histoplasma

SE

  • Adrenal insuffiency
  • Gynocomastia
  • Leg edema
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Voricnalzole

Penetration
Unique SE
Use

A

Benefits
- Well absorbed & good CNS penetrations

SE
- Visual distrubances

Use
- Evasive aspergilosis, candidia, cryptocis, prophlaxis for neurtropenia & GVHD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Drug for zygomycosis

A

Posaconazile

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Candida infections drug

A

Fluconazole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Amphotericin B4

A

MOA
Bind to ergosterols to create membrane pores

Use
Systemic infections with Candida, cryptociccus, dimorphics, aspergillus & mucormycosis

SE
Renal toxicity - damgeds distal tubule membrane = electrolyte wasting - constriction of afferent arteriore = acute kidney failure
Supress Epo production
Infusion related reactions (sweats chills & rigors)
Renal toxicity is worth with other renally toxic drugs
Manage toxicity with acetiminophen, diphenhydramine & replace salts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

liquid based formulations of amphotericin B

  • Benefits
A

Less toxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Lipid formulation of amphotericin

A

Safer?

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Echinocandins

A

Use

  • Candida
  • Aspegillosis

MOA
- Ihibits B(1,3) glucan synthase leading to dysfuctional cell wall

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Caspofungin

Formulation
SE

A

Formulation
- IV formulation

SE
- Hepatits

USE

  • Resistant candidia species
  • 3rd line aspegillosis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Systemic candiasis

A

fluconaxole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Aspegilosis especially in CNS

A

Voriconazole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly

Year II Pharmacology Term 5 (9 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions