HIV Drugs

Question 1

Targets

Answer 1

Life cycle

Question 2

nRTI AZT or Abacavir

Mechanism

Answer 2

Lack OH moity so cannot eleongate the chain

Question 3

Abacavir Hypersensitivity

Answer 3

HLA-B-5701

• Slower progression to aids
• Autoiimne disease
• Deadly on second exposure to the drug

Question 4

nRTI SEs

Answer 4

1. Fat redistribution
2. Lactic acidosis (mitochondiral toxicity)
3. Abacavir hypersensivity

Question 5

nnRTI

Mechanism

Answer 5

Inhibit chain elongation by binding elsewhere (not the active site) of the reverse transcriptase

Question 6

Protease inhibitors

Mechanism

Answer 6

Blocks elongation by mimicking structure of peptides the protease should cleave

Question 7

PI - what is boosted?

Answer 7

PIs intefer with CYP450 metabolism so can reach high systemic levels with few pills

Question 8

Genetic mutation that reduces chances of HIV infection

Answer 8

CCR5 antagonists

Question 9

Top 3 barriers to curing HIV

Answer 9

Latency (integrase inhibitors)

HIV mutability

Question 10

Life expectancy if on HIV treatment

Answer 10

Unchanged!

Question 11

CD4

Answer 11

PCP

TMP-SMX/dapsoone

Question 12

CD4

Answer 12

Toxoplasmosis

same + pyrimethmol

Question 13

CD4

Answer 13

MAC, CMV, Crypto & KS

Azithromycin

Question 14

HAART requirements

Answer 14

2 classes with at least 3 drugs

Question 15

Biggest curve ball

Answer 15

NON ADHERENCE

Question 16

HIV prophlaxis

Answer 16

Antiviral therapy
Condoms
Microbicides
Circumcision
Treatment for prevention