Antifungals Flashcards
Discuss mechanisms of actions of antifungals
1
Q
Polyenes
A
MoA - forms a pore leading to cell leakage
-binds more avidly to ergosterol than cholesterol
Nyastatin used topically
Amphotericin B also used and encapsulated in lipid to prevent nephrotoxicity
2
Q
Azoles
A
MoA - block ergosterol synthesis
- Fluconzaole - high bioavailability and good for yeasts
- Iteraconzaole and voriconzaole - good for molds and latter has broader spectrum and higher bioavailability
- Posaconzaole - good against opportunistic molds
3
Q
Allylamines
A
MoA - block ergosterol synthesis
- Terbinafine only one available for parenteral use
- used for dematophyte infections
- Naftifine is topical
4
Q
Flucytosine
A
MoA - block DNA/RNA synthesis
- used w/ amphotericin B to reduce chances of resistance
- Can cause bone marrow toxicity due to build up of 5-FU
5
Q
Echiocandins
A
MoA - block glucan synthesis on cell walls
- Caspofungin, anidulofungin, micafungin: all are equally effective
- Good for Candida treatment
- Also used for prophylaxis or salvage therapy of aspergillosis
