Antibacterials and anitivirals

Question 1

Cell Wall Inhibitors

Answer 1

• BETA LACATAMS
o Inhibit PBPs which catalyze last step of PG synthesis
o Site of action at inner cell membrane
o Time dependent killing
o Toxicity
• GI side effects (higher with oral compared to IV)
• Hypersensitivity – greater with penicillin
• Non-IgE mediated rash
o Drug ix
• Synergetic with aminoglycosides