Antifungals

Question 1

what predisposes you to serious fungal infec

Answer 1

immuncompromised
broad spectrum antibac use
indwelling catheters

Question 2

difficulty in treating fungal infec

Answer 2

eukaryotes
few agents
infec in poorlky vascularized places (skin, nails, hair)

Question 3

classifcation of mycoses

Answer 3

systemic (could be fatal)

superficial (mucous membranes, dermatophytic)

Question 4

antifungals target

Answer 4

membranes - ergosterol
nucleic acids -limited
cell wall

Question 5

side effects of fluconazole, itraconazole, voriconazole

Answer 5

nausea vomiting rash diarrhea headache
mild hepatotoxicity (fluconazole is lowest)
inhibit metabolism of several other drugs–inhibitor of cytochrome P450s (CYP3A and 2C)

Question 6

warning for itraconazole

Answer 6

don’t give with other drugs metabolized by CYP3A4

Question 7

voriconazole particular side effect

Answer 7

visual distrubances

photosensitive aspect of rash

Question 8

major causes of mucous membrane fungal infec

Answer 8

candida