Antifungal List for Exam 1 CMOD

Question 1

Voriconazole

Drug Class
MOA
Side Effects
Administration method 
Important Facts
Fungi Treated

Answer 1

Drug Class
Azole

MOA
Inhibtion of 14alpha-steroidemethylase preventing Ergosterol sythesis

Side Effects
PHOTOSENSITIVE DERMATIS, TERMPORY VISUAL ISSUES, HALLUCINATIONS, Cardiac Issues, CYP3A4 inhibition =>DRUG-DRUG interactions, Hepatic Toxicity

Administration method
IV

Important Facts
Penetrates to CSF, DO NOT GIVE TO PREGNANT WOMEN

Fungi Treated
Aspergillosis (IV)`

Question 2

TERBINAFINE

Drug Class
MOA
Side Effects
Administration method 
Important Facts
Fungi Treated

Answer 2

Drug Class

MOA
Blocks Ergosterol Synthesis, Prevents squalene conversion to Squalene Epoxide via SQUALENE OXIDASE inhibition

Side Effects
Transient Lymphopenia and Neutropenia

Administration method
???

Important Facts
NO CYP ACTIVITY; Avoid use in Immunosuppressed patient, Routine CBCs

Fungi Treated
????

Question 3

Posaconazole

Drug Class
MOA
Side Effects
Administration method 
Important Facts
Fungi Treated

Answer 3

Drug Class
Triazole

MOA
Inhibtion of 14alpha-steroidemethylase preventing Ergosterol sythesis

Side Effects
Cardiac Issues, CYP3A4 inhibition =>DRUG-DRUG interactions, Hepatic Toxicity

Administration method
PO

Important Facts
Most Instances of Adverse effects

Fungi Treated
Mucormycosis

Question 4

Nystatin

Drug Class
MOA
Side Effects
Administration method 
Important Facts
Fungi Treated

Answer 4

Drug Class

MOA
Binds to ERGOsterols in the Fungal Cell membrane, Forms a pore and causes cell death (amphipathic)

Side Effects
Reduced Because of Topical Application

Administration method
TOPICAL

Fungi Treated
Candidasis (mococutaneous, orphopharyngeal, vulvovaginal)

Question 5

Micofungin

Drug Class
MOA
Side Effects
Administration method 
Important Facts
Fungi Treated

Answer 5

Drug Class
Echinocandins

MOA

Side Effects
Infusion Reactions

Administration method
IV

Important Facts
?????

Fungi Treated
Apergillis, Candida

Question 6

Ketoconazole

Drug Class
MOA
Side Effects
Administration method 
Important Facts
Fungi Treated

Answer 6

Drug Class
Imidizole

MOA
Inhibtion of 14alpha-steroidemethylase preventing Ergosterol sythesis

Side Effects
ADRENAL deficiency, Cardiac Issues, CYP3A4 inhibition =>DRUG-DRUG interactions, Hepatic Toxicity

Administration method
?????

Important Facts
No ability to penetrate into CSF

Fungi Treated
??????

Question 7

Drug Class
MOA
Side Effects
Administration method 
Important Facts
Fungi Treated

Answer 7

Drug Class

MOA

Side Effects

Administration method

Important Facts

Fungi Treated

Question 8

ITRACONAZOLE

Drug Class
MOA
Side Effects
Administration method 
Important Facts
Fungi Treated

Answer 8

Drug Class
Triazole

MOA
Inhibtion of 14alpha-steroidemethylase preventing Ergosterol sythesis

Side Effects
Cardiac Issues, CYP3A4 inhibition =>DRUG-DRUG interactions, Hepatic Toxicity

Administration method
PO

Important Facts
Most Instances of Adverse effects

Fungi Treated
Blastomycosis (mild or severe, PO), Coccidiomycosis (PO), Histoplasmosis (PO), Sprotrichosis (PO)

Question 9

Griseofulvin

Drug Class
MOA
Side Effects
Administration method 
Important Facts
Fungi Treated

Answer 9

Drug Class
Cell Cycle Inhibitor

MOA
Inhibits Production of Microtubules, which prevents replication

Side Effects
CYP3A4 Drug-Drug interactions (e.g. Warfarin, oral contraceptives, Cyclosporin)

Administration method
????

Important Facts
?????

Fungi Treated
????

Question 10

FLUCOSINE

Drug Class
MOA
Side Effects
Administration method 
Important Facts
Fungi Treated

Answer 10

Drug Class
Cell Cycle Inhibitor

MOA
Enters through Cytosine Permease and gets converted to 5-Flurouracil (an anticancer drug) to inhibit Thymidylate synthase ***Humans can’t convert it to 5-Flurouricil, but G.I. bacteria can

Side Effects
ANEMIA, LEUKOPENIA, etc. all side effects associated with cancer drugs b/c intestinal flora convert it to 5-flurouricil

Administration method
PO

Important Facts
Narrow Therapeutic Window

Fungi Treated
Cryptococcus (PO, w/ Amp. B)

Question 11

FLUCONAZOLE

Drug Class
MOA
Side Effects
Administration method 
Important Facts
Fungi Treated

Answer 11

Drug Class
Triazole

MOA
Inhibtion of 14alpha-steroidemethylase preventing Ergosterol sythesis

Side Effects
Cardiac Issues, CYP3A4 inhibition =>DRUG-DRUG interactions, Hepatic Toxicity

Administration method
PO or IV

Important Facts
**Best drug with the widest therapeutic index; ELIMINATED IN URINE, NOT LIVER; DO NOT GIVE TO PREGNANT WOMEN. IC

Fungi Treated
Candidiasis (PO),Coccidiodomycosis (IV/PO), Crytococcus (PO)

Question 12

CASPOFUNGIN

Drug Class
MOA
Side Effects
Administration method 
Important Facts
Fungi Treated

Answer 12

Drug Class
Echinocandins

MOA
ß (1,3) glucan synthesis Inhibitor

Side Effects
Infusion Reactions; Hepatic Toxicity

Administration method
IV

Important Facts
???????

Fungi Treated
Apergillis, Candida

Question 13

AMPHOTERICIN B

Drug Class
MOA
Side Effects
Administration method 
Important Facts
Fungi Treated

Answer 13

Drug Class

MOA
Binds to ERGOsterols in the Fungal Cell membrane, Forms a pore and causes cell death (amphipathic)

Side Effects
Infusion Reactions; Renal Toxicity => Anemia, Cardiac Dysfunction; Hepatic issues

Administration method
IV

Important Facts
?????

Fungi Treated
Blastomycosis (severe), Crytococcus (w/ Flucosine PO), Histoplasmosis, Mucormycosis, Sporotrichosis