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PHARMACOLOGY - Antibiotics and Immunosuppressives > Anti-inflammatory List for Exam 1 CMOD > Flashcards

Anti-inflammatory List for Exam 1 CMOD Flashcards

1
Q

Acetominophen

Alternate Name
Drug Class
MOA
Notable Side Effects
Diseases Treated
A

Alternate Name:
Tylenol

Drug Class:
NSAID

MOA:
Unknown - antipyretic

Notable Side Effects:
Liver necrosis

Diseases Treated:
errthang

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2
Q

Acetylsalicylic Acid

Alternate Name
Drug Class
MOA
Notable Side Effects
Diseases Treated
A

Alternate Name:
Asprin

Drug Class:
NSAID

MOA:
Nonselectively, Irreversibly Acetylates COX

Notable Side Effects:
GI Bleeds
Renal Failure

Diseases Treated:
errthang

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3
Q

Adalimumab

Alternate Name
Drug Class
MOA
Notable Side Effects
Diseases Treated
A

Drug Class:
mAb (monoclonal)

MOA:
mAb for TNF-alpha receptors using Fc region to promote OPSONIZATION, ADCC, Complement Fixation

Diseases Treated:
Ankylosiing Spondylitis, Crohn’s, Juvenile RA, JIA,

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4
Q

Beclomethasone

Alternate Name
Drug Class
MOA
Notable Side Effects
Diseases Treated 
Method of Administration
A

Alternate Name:

Drug Class:
Glucocorticoid

MOA:
Inhibition of Phosopholipase-2 to block COX and LOX pathways and Competes with GATA-3 for nuclear transport leading to down regulation of inflammatory mediators like IL-13, IL-5, and IL-6, and IL-2

Notable Side Effects:
CV risk, Cataract Glaucoma, Hirsutism, Cushings, Insulin resistance, Osteoporosis(necrosis), Infections

Diseases Treated:
Asthma

Method:
Inhaled

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5
Q

Bortezomib

Alternate Name
Drug Class
MOA
Notable Side Effects
Diseases Treated
A 
Alternate Name:
------------------
Drug Class:
-------------------
MOA:
Binds to IkB preventing Ub. Presence of IkB prevents NfkB from transcribing genes (like VEGF, IL-6, and VCAM-1)

Notable Side Effects:
¿CV risk, Cataract Glaucoma, Hirsutism, Cushings, Insulin resistance, Osteoporosis(necrosis), Infections?

Diseases Treated:

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6
Q

Celexcoxib

Alternate Name
Drug Class
MOA
Notable Side Effects
Diseases Treated
A

Alternate Name:
Celebrex

Drug Class:
NSAID

MOA:
COX-2 Inhibitor

Notable Side Effects:
CV risk

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7
Q

Certolizumab Pegol

Alternate Name
Drug Class
MOA
Notable Side Effects
Diseases Treated
A

Alternate Name:

Drug Class:
mAb

MOA:
mAb TNF-alpha receptors, NO Fc Region (cannot fix complement etc.), DRUG WORKS EVEN W/O ADCC and COMP. FIX

Diseases Treated:
Crohn’s, Psoriasis, Rheumatoid Arthritis

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8
Q

Cetirizine

Alternate Name
Drug Class
MOA
Notable Side Effects
Diseases Treated
A

Drug Class:
Anti-histamine

MOA:
2nd generation Antihistamine (H1 blocker) - Doesn’t cross BBB

Diseases Treated:
——————

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9
Q

Chorpheniramine

Alternate Name
Drug Class
MOA
Notable Side Effects
Diseases Treated
A

Drug Class:
Anti-histamine

MOA:
1st generation Antihistamine (H1 blocker) - Crosses BBB (anticholenergic)

Notable Side Effects:
Drowsiness

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10
Q

Dimethylhydrinate

Alternate Name
Drug Class
MOA
Notable Side Effects
Diseases Treated
A

Drug Class:
Anti-histamine

MOA:
1st generation Antihistamine (H1 blocker) - Crosses BBB (anticholenergic)

Notable Side Effects:
Drowsiness

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11
Q

Diphenhydramine

Alternate Name
Drug Class
MOA
Notable Side Effects
Diseases Treated
A

Alternate Name:
Benedryl

Drug Class:
Anti-histamine

MOA:
1st generation Antihistamine (H1 blocker) - Crosses BBB (anticholenergic)

Notable Side Effects:
Drowsiness

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12
Q

Etancercept

Alternate Name
Drug Class
MOA
Notable Side Effects
Diseases Treated
A

Drug Class:
Protein Fusion

MOA:
Binds to TNF extracellular Ligand binding portion + Fc of IgG1

Diseases Treated:
Ankylosiing Spondylitis, Juvenile RA, JIA, Psoriasis, Psoriatic Arthritis, Rheumatoid Arthritis

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13
Q

Fexofenadine

Alternate Name
Drug Class
MOA
Notable Side Effects
Diseases Treated
A

Alternate Name:
Allegra

Drug Class:
Anti-histamine

MOA:
2nd generation Antihistamine (H1 blocker)

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14
Q

Ibuprofen

Alternate Name
Drug Class
MOA
Notable Side Effects
Diseases Treated
A

Alternate Name:
Advil

Drug Class:
NSAID

MOA:
non-specific COX inhibition

Notable Side Effects:
GI Bleeds
Renal Failure

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15
Q

Indomethacin

Alternate Name
Drug Class
MOA
Notable Side Effects
Diseases Treated
A

Alternate Name:
Aleve

Drug Class:
NSAID

MOA:
non-specific COX inhibition

Notable Side Effects:
GI Bleeds
Renal Failure

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16
Q

Infliximab

Alternate Name
Drug Class
MOA
Notable Side Effects
Diseases Treated
A

Drug Class:
mAb

MOA:
mAb TNF-alpha receptors, Fc Region for OPSONIZATION( complement Fixation and ADCC)

Diseases Treated:
Ankylosiing Spondylitis, Crohn’s, Psoriasis, Psoriatic Arthritis, Rheumatoid Arthritis, Ulcerative Colitis

17
Q

Loratadine

Alternate Name
Drug Class
MOA
Notable Side Effects
Diseases Treated
A

Drug Class:
Anti-histamine

MOA:
2nd generation Antihistamine (H1 blocker)

18
Q

Montelukast

Alternate Name
Drug Class
MOA
Notable Side Effects
Diseases Treated
A

Drug Class:
Leukotriene Receptor BLOCKER

MOA:
Leukotriene Receptor Blocker

19
Q

Naproxen

Alternate Name
Drug Class
MOA
Notable Side Effects
Diseases Treated
A

Alternate Name:

Drug Class:
NSAID

MOA:
Non-selective COX, reversible

Notable Side Effects:
GI problems
Renal Dysfunction

20
Q

Omalizumab

Alternate Name
Drug Class
MOA
Notable Side Effects
Diseases Treated
A

Alternate Name:
Xolair

Drug Class:
mAb-IgE

MOA:
Binds IgE from binding anti-IgE antibody, mast cells are full of hisamine but no signal ever arrives

Diseases Treated:
Asthma

21
Q

Prednisone

Alternate Name
Drug Class
MOA
Notable Side Effects
Diseases Treated
A

Drug Class:
Glucocorticoid

MOA:
Inhibition of Phosopholipase-2 to block COX and LOX pathways and Competes with GATA-3 for nuclear transport leading to down regulation of inflammatory mediators like IL-13, IL-5, and IL-6, and IL-3

Notable Side Effects:
CV risk, Cataract Glaucoma, Hirsutism, Cushings, Insulin resistance, Osteoporosis(necrosis), Infections

22
Q

Promethazine

Alternate Name
Drug Class
MOA
Notable Side Effects
Diseases Treated
A

Drug Class:
Anti-histamine

MOA:
1st generation Antihistamine (H1 blocker) - Crosses BBB

Diseases Treated:
—————-

23
Q

Roflumilast

Alternate Name
Drug Class
MOA
Notable Side Effects
Diseases Treated
A

Drug Class:
RDE4 inhibitor

MOA:
Inhibits phosphodiesterase-4 (PDE4), Blocks hydrolyses and inactivation of cAMP, They aren’t sure why this works

24
Q

Zileuton

Alternate Name
Drug Class
MOA
Notable Side Effects
Diseases Treated
A

Drug Class:
Leukotriene Synthesis Inhibitor

MOA:
Leukotriene Synthesis Inhibitor

PHARMACOLOGY - Antibiotics and Immunosuppressives (12 decks)

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