Antifungal Drugs Flashcards
Amphotericin B (fungizone) MOA
leaky cell wall
Amphotericin B (fungizone) adverse effects
fever, chills, body aches
N/V
nephrotoxicity
phlebitis
bone marrow suppression
hepatic, renal
hypotension
hypoxia
hypomagnensemia
hypokalemia
paresthesia
visual disturbances
Amphotericin B (fungizone) interactions
nephrotoxic drugs
drugs that dec bone marrow
cardiac glycosides (digoxin, diuretics)
Amphotericin B (fungizone) contraindications
renal impairment
Amphotericin B (fungizone) nursing
slow IV 2-4 hrs (can cause seizures)
give with NS to dec nephrotoxicity
BUN, liver enzymes, electrolytes
alternate day dosing
premeditate with antihistamine, antiemetic, antipyretic
Itraconazole (sopranox) adverse effects
N/V/D
arthralgia
edema
hyperglycemia
cardiac failure
hepatotoxicity
Itraconazole (sopranox) interactions
digoxin
warfarin
sulfonylurea type hypoglycemic
Itraconazole (sopranox) contraindications
CHF
Fluconazole (diflucan) adverse effects
N/V
HA
abd pain
increased liver enzymes
Fluconazole (diflucan) interactions
warfarin
phenytoin
BC
Fluconazole (diflucan) contraindications
caution with liver and renal dysfunction
Fluconazole (diflucan) nursing
watch liver and renal function
