Anti-Anginals Flashcards
nitrates/nitrites MOA
inc. supply and dec. demand
acts directly on vascular smooth muscle
dilates veins = dec. preload
nitrates/nitrites uses
all forms of angina
long acting for prophylaxis
rapid acting for acute
nitrates/nitrites contraindications
hypotension
inc. ICP
glaucoma
ED meds
anemia
allergy
nitrates/nitrites interactions
anti-HTN
ETOH
ED meds
nitrates/nitrites adverse effects
reflex tachycardia
orthostatic hypotension
dizziness/syncope
HA
diminish with use/ get more tolerant
to avoid nitrates/nitrites tolerance
use lowest effective dose
long action need 8 hr pd
reverse by withholding for a short pd
D/C nitrates/nitrites
slowly to avoid vasospasms
calcium channel blockers uses
chronic stable angina
variant angina
calcium channel blockers interactions
digoxin
betablockers
grapefruit juice
calcium channel blockers cautious use in patients with:
AV heart block
calcium channel blockers adverse effects
bradycardia or reflex tachycardia
hypotension
constipation
HA/dizziness
edema
flushing
calcium channel blockers MOA
inc. supply and dec. demand
block Ca channels VSM = arterial dilation and dec. peripheral resistance
dec. afterload
beta blockers MOA
dec. oxygen demand
block beta 1 receptors on the heart = heart in diastole longer = inc. perfusion
dec. workload on heart
beta blockers uses
exercise induced angina
beta blockers cautious use in patients with:
heart failure
AV block
DM
