Antifungal Agents Flashcards
A compound of a rigid cell wall made up of chitin and various polysaccharides, and a cell membrane contains ergosterol
Fungus
Which type of patients are susceptible to fungal infections
- Patients with AIDS & AIDS-related complex (ARC)
- Patients taking immunosuppressant drugs
- Patients who have undergone transplantation surgery or cancer Rx
- Elderly
These alter the cell permeability leading to leakage of cellular component
Systemic antifungals
The drug binds to the sterols in the fungus cell wall changing the cell permeability
Amphotericin B
What type of fungal infections are Amphotericin B?
Fatal fungal infections
How is Amphotericin B administered?
Given IV and excreted in the urine
When would you not give a patient Amphotericin B?
When the patient has kidney disease
What are the adverse reactions of Amphotericin B?
Kidney failure
What is Nystatin used to treat?
Intestinal candidiasis (thrush)
Athletes foot is treated with which antifungal agent?
Terbinafine
Which drug is used for treat systemic fungal infections and is less toxic than Amphotericin B, but also less effective than Amphotericin B?
Azoles
What is Fluconazole used to treat?
Yeast infections in the esophagus/GI tract
When would you not give a patient Fluconazole?
When the patient has renal dysfunction
What are the overall adverse reactions of systemic antifungal agents?
- CNS effects
- GI effects
- Heptic dysfunction
- Dermatologic effects
- Renal dysfunction
For what infections would you use topical antifungal treatment?
Ringworm, athletes foot, jock itch, and yeast infections
