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naplex pnn > antifungal > Flashcards

antifungal Flashcards

1
Q

what antibiotics works in cell synthesis?

A

-PCN , CPN, carbapenem, aztreonam

-Vancomycin, televancin, Oritevancin

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2
Q
  • abx with 50 s inbibitor MOA?
A

Erythromycin
Clarithromyicn
Linezolide/ Tedizolid

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3
Q

Abx with 30s MOA

Protein synthesis 30 s Inhibitor

A

Aminoglycoside
Tetracycline

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4
Q

ABX that work on DNA gyrase

A

Quinolone

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5
Q

Abx that works on DNA synthesis

A

Metronidazole

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6
Q

Abx that works on inhibiting transcription of DNA to mRNA

A

Rifaximin

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7
Q

ABX that work on phospholipid membrane

A

Polymixin B

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8
Q

Antifungal that works on cell Nucleic acid Synthesis

A

Flucytosine

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9
Q

Anti-fungal that works on
cell wall

A

Caspofungin
Anidulafungin (Eraxis)
Ibrexafungerp (Bexafeme)

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10
Q

Anti-fungal that works on DECREASING ERGOSTEROL SYNTESHIS AND INHIBITING CELL WALL MEMBRANE

IT WORK ON CYTOCHROME 450 ACTIVITY

A

AZOLE

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11
Q

Antifungal that binds to cell membrane altering membrane permeability

A
  • Amphotericn B
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12
Q

Amphotericin B

*AMpho D

A

MOA:
- Binds to ergosterol

  1. SE
    Infusion related shaking chills, hypotension, Nephrotoxicity, dec in K, Mg
  2. Dosing conc for infusion
    - **1mg/10mL **
    - Ampho D.. give in Dextrose

Amphotericin in DEXTROSe
Ampho B conc is 1mg/10ml

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13
Q

Ampho B lipid forumulation

A
  • Abelcet
  • Ambisome
  • Amphotec
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14
Q

AMpho B lipid form less toxic and must meet one criteria to use Lip formualtion

A
  1. Significant renal imp (CrcL<50 ors Scr>2.4)
  2. Patient unable to tolerate regular Ampo
  3. Transplant recipient
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15
Q

conventional ampho b

A
  1. protect from moisture, light and refrigerated
  2. reconstitue w/steriler water then mix with D5W

store in dark at room after reconstituion

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16
Q

Azole antifungal

A

fluconazole
Itraoconazole
voriconazole
ketoconazole
isavuconazonium

17
Q

Azole antifungal

A

MOA: dec ergosterol synthesis

SE: Hepatoxicity

DUR: CYP450 3A4
- (Inc warfarin)

- itraconazole and ketoconazole need acidic env- take with food

18
Q

Fluconazole

A

Difulcan
indication
- vaginal candidadis
- Oropharngeal/ esophageal
- Crytococal menigtis

Pregnancy: 150mg is Category C . CDC recom only topical atifungal (vagin

19
Q

Itraconazole

A

Sporanax

Dose: 200mg PO QD X 12 wks for Onchomycosis

  • used for Aspergillus

SE: Hepatoxicity and neg Inotrope

CYP3A4 substrate and Inhib

20
Q

ketoconazole

A

Nizoral
Form/Indication
- 1% shampoo:
- 2% shampoo for Tinea versicolor
- systemica fungal infection

Needs acidic env
CYP3A4 substrate and inhib

tineas versicolor: discoloration patch of skin; overgrowht of type of ye

21
Q

Voriconazole

A

VFend
Indication
- Aspergillus
- forms : Tab, Inj, susp
- EMPTY STOMACH

WARNNG
VORICONAZOLE
O: OPTIC (Monitor for vison imp)
O: Photosensitivity
O: QT
C: CNS

cyp3A4 substrate and inhib

22
Q

isavuconazonium

A

Cresemba
Indication
- Aspergillus
- oral/ IV
- major CYP3A4 substrate

23
Q

Caspofungin

A

Cancidas
MoA: Inhibits cell wall
Indication
- Aspergillosis
- dilute in NS or lactated ringer

24
Q

Anidalfungin

A

Eraxis

IV

25
Q

Posconazole

A

Noxafil

MOA: inhibit ergosterol synthesis
Indication
- prevent/tx invasive aspergillos
- oral susp
- avoid in renal imp Crcl <50

26
Q

Clotrimazole

A
  • topical for athlete foot
  • troch lonzes for oral thrush
  • gyne-lotrimin for vaginal yeast inf
  • vaginal tablet for vaginal yeast inf
27
Q

Nystatin

A

Topical and oral
oral thrush: swish and swallow

28
Q

terbinafine

A

Lamisil
MOA: inhibits ergosterol synthesis
indication
- fingernail for 6 wks
- toenail for 12 weeks

29
Q

Ciclopirox

A

Penlac- top solution

topical nail lacquer for onchomycosis of fingernails and toenails

30
Q

Efinacazole

A

Jublia

QD for 48 weeks

31
Q

therpy for onchomycosis

A

PO
- terbinafine (lamisi)
- itraconazole (Sporonax)

Topical
- Ciclopirox (Penlac)
- Efinacozole (Jublia)
- Tea tree oil

32
Q

flucytosine

A

Ancobon

PO

synergestic with ampho B or fluconazole in cryptococcal menigntis

naplex pnn (12 decks)

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