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step1 > antiepleptics > Flashcards

antiepleptics Flashcards

1
Q

benzoz

A

inc gaba action
sedation ,tolerance ,dependance ,respiratory depression
status eplipticus `
also for eclampsia seizures,

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2
Q

carbamezepine

A 
in status epilepticus
blocks na channels 
diplopia ataxia ,blood dyscrasias aganulocytosis ,aplastic anemia 
liver toxcicity 
teratogen
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2
Q

carbamezepine

A 
in status epilepticus
blocks na channels 
diplopia ataxia ,blood dyscrasias aganulocytosis ,aplastic anemia 
liver toxcicity 
teratogen
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3
Q

carbamezepine

A 
in status epilepticus
blocks na channels 
diplopia ataxia ,blood dyscrasias aganulocytosis ,aplastic anemia 
liver toxcicity 
teratogenesis
induction of cytochrome 9450
siadh 
sjs 
1st line treatment of trigeminal neuralgia
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4
Q

ethosuximide

A

absence seizures\
block thalamic t type ca channels
causes fatigue ,gi distress ,headache ,itching ,sjs

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5
Q

gabapentin

A

partial focal seizures
primarily inhibits high voltage activated ca channels designed as gaba analog
se sedation ataxia
used for perfipheral neuropathy and post herpetic neuralgia

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6
Q

lamotigrine

A

focal seizures ,tonic colonic absence
block voltage gated na channels inhibits the release of glutamate
sjs
hemophagocytic lymphocytosis

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7
Q

levitiracetam

A

partial ,tonic colonic , sv2 receptor blocker may modulate gaba release inhibit voltage gated ca release
neuropyschiatric symp, fatigue , drowsiness ,headache

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8
Q

phenobarbital

A

partial ,tonic colonic ,status eplipticus
inc gaba action
sedation tolerance, dependance ,induction of pyshc p450
cvs depression
1st line in neonates

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9
Q

phenytoin

A 
partial status eplipticus 
toxciitiy ataxia sedation diplopia
blocks na channels 
p450 induction
pseudolymphoma
hirsutisim 
enlarged gum
nystagmus 
yellow brown skin 
teratorgenic 
osteopenia 
neuropathy 
sjs dress ,
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10
Q

topiramate

A 
blocks focal and tonic colonic 
blocks na channels inc gaba action 
slow sedation ,stones ,skinny 
sighthreatened ,speech difficulties
migraine prophylaxis
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11
Q

valporic acid

A 
focal ,tonic colonic ,absence 
in na channel inactivation 
in gaba conc by inhibiting gaba transaminase
vomiting 
alopecia
liver damage 
pancreatitis 
p450 
rash temor teratogenic 
epigastric pain 
myocolonic seizures ,bipolarr mirgraine prophylaxis
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12
Q

vigabtrin

A

inc gaba irreversible gaba transaminase inhibitor permenant visual loss

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