Antidotes for the USMLE

Question 1

Acetaminophen antidote?

Answer 1

N-acetylcysteine

Question 2

AChE inhibitors, organophosphate antidotes (sequence)

Answer 2

Atropine followed by pralidoxime

Question 3

Amphetamine antidote?

Answer 3

Ammonium chloride

Question 4

Antimuscarinic, anticholinergic agent antidote?

Answer 4

Physostigmine salicylate (and control hyperthermia)

Question 5

Benzodiazepine antidote?

Answer 5

Flumazenil

Question 6

B-blocker antidote?

Answer 6

Glucagon

Question 7

Carbon monoxide antidote?

Answer 7

100% O2/hyperbaric O2

Question 8

Copper, arsenic, gold antidote?

Answer 8

Penicillamine

Question 9

Cyanide antidotes? (3)

Answer 9

Nitrite + thiosulfate, hydroxocobalamin

Question 10

Digitalis antidote?

Answer 10

Anti-dig Fab fragments

Question 11

Heparin antidote?

Answer 11

Protamine sulfate

Question 12

Iron antidote? (2 possible)

Answer 12

Deferoxamine (IV), Deferasirox (oral)

Question 13

Lead antidotes? (4)

Answer 13

EDTA, dimercaprol, succimer, penicillamine

Question 14

Mercury, arsenic, gold antidotes? (2)

Answer 14

Dimercaprol, succimer

Question 15

Methanol, ethylene glycol (antifreeze) antidotes? (3)

Answer 15

Fomepizole > ethanol, dialysis

Question 16

Opioid antidote?

Answer 16

Naloxone

Question 17

Salicylate antidotes? (2)

Answer 17

Sodium bicarbonate (alkalinize urine), dialysis

Question 18

TCA antidote?

Answer 18

Sodium bicarbonate (alkalinize plasma)

Question 19

tPA, streptokinase, urokinase antidote?

Answer 19

Aminocaproic acid

Question 20

Warfarin antidote? (2)

Answer 20

Vitamin K, FFP if active bleeding