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Pharm 2 > Antidepressants and Lithium > Flashcards

Antidepressants and Lithium Flashcards

1
Q

Desvenlafaxine

A

Third Generation Antidepressant

Mech: SNRIs

Inhibit reputake of 5HT and NE

*Third generations have the -faxine drugs

SE:

GI upset
Nausea
Insomnia
Headache
Decreased libido
Cardiovascular stimulation

*SE same as 2nd gen +cardio stim.

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2
Q

Citalopram

A

2nd gen antidepressant

Mech: SSRIs

SE:

GI upset
Nausea
Insomnia
Headache
Decreased libido

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4
Q

Second generation antidepressants

A

Fluoxetine

Fluvoxamine

Sertraline

Paroxetine

Citalopram

Escitalopram

Vilazodone

Vortioxetine

Mech: SSRIs

SE:

  • GI upset
  • Nausea
  • Insomnia
  • Headache
  • Decreased libido
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5
Q

Third Generation antidepressants

A

Venlafaxine

Desvenlafaxine

Duloxetine

Milnacipram

Mech: SNRIs

Inhibit reputake of 5HT and NE

*Third generations have the -faxine drugs

SE:

  • GI upset
  • Nausea
  • Insomnia
  • Headache
  • Decreased libido
  • Cardiovascular stimulation

*SE same as 2nd gen +cardio stim.

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6
Q

Sertaline

A

2nd gen antidepressant

Mech: SSRIs

SE:

GI upset
Nausea
Insomnia
Headache
Decreased libido

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6
Q

Paroxetine

A

2nd gen antidepressant

Mech: SSRIs

SE:

GI upset
Nausea
Insomnia
Headache
Decreased libido

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7
Q

Venlafaxine

A

Third Generation Antidepressant

Mech: SNRIs

Inhibit reputake of 5HT and NE

*Third generations have the -faxine drugs

SE:

GI upset
Nausea
Insomnia
Headache
Decreased libido
Cardiovascular stimulation

*SE same as 2nd gen +cardio stim.

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7
Q

Fluvoxamine

A

2nd gen antidepressant

Mech: SSRIs

SE:

GI upset
Nausea
Insomnia
Headache
Decreased libido

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9
Q

Vortioxetine

A

2nd gen antidepressant

Mech: SSRIs

SE:

GI upset
Nausea
Insomnia
Headache
Decreased libido

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10
Q

Milnacipram

A

Third Generation Antidepressant

Mech: SNRIs

Inhibit reputake of 5HT and NE

*Third generations have the -faxine drugs

SE:

GI upset
Nausea
Insomnia
Headache
Decreased libido
Cardiovascular stimulation

*SE same as 2nd gen +cardio stim.

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11
Q

Nefazodone

A

Antidepressant

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12
Q

Antipsychotic drugs used to treat mania

A

Phenothiazine

Haloperitol

Benzos

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13
Q

Duloxetine

A

Third Generation Antidepressant

Mech: SNRIs

Inhibit reputake of 5HT and NE

*Third generations have the -faxine drugs

SE:

GI upset
Nausea
Insomnia
Headache
Decreased libido
Cardiovascular stimulation

*SE same as 2nd gen +cardio stim.

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14
Q

Vilazodone

A

2nd gen antidepressant

Mech: SSRIs

SE:

GI upset
Nausea
Insomnia
Headache
Decreased libido

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15
Q

Mirtazapine

A

Antidepressant

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16
Q

Other tx of bipolar

A

Most are antiseizure:

  • Valproic acid
  • Carbamazepine
  • Limotripene

Acetazolamide

Aripripazole-anti-psychotic

17
Q

Fluoxetine

A

2nd gen antidepressant

Mech: SSRIs

SE:

GI upset
Nausea
Insomnia
Headache
Decreased libido

18
Q

MAO inhibitors

A

Tranylcypromine

Phenelzine

Isocarboxazid

Mech: Irreversibly inhibits metab of NE and 5HT (via inhibition of MAO)

Kinetcs: Slow onset

Toxicity:

  • Insomnia
  • Agitation
  • Hallucination
  • Seizure
  • Liver toxicity
  • Weight gain
  • Hypotension
  • Great increase in likelihood of suicide in children

Drug interactions:

  • Indirect acting amines→Hypertensive crisis
    • Some foods contain tyramine (smoked foods, aged cheeses, wine)
19
Q

Escitalopram

A

2nd gen antidepressant

Mech: SSRIs

SE:

GI upset
Nausea
Insomnia
Headache
Decreased libido

20
Q

First Gen Antidepressants

A

Impiramine + Amitryptyline

Tricyclic antidepressants

Mech: Inhibit NE reuptake

Act on multiple receptors

SE:

  • Most likely to cause SE
  • Sedation
  • Weight gain
  • Anticholinergic effect (dry eyes, dry mouth, constipation)
  • Cardiovascular effects
    • Arrythmias
    • Drop in BP (alpha1 block)
    • Orthostatic hypotension
21
Q

Lithium

A

Tx: Mania

Used prophylactically–5-7 day onset

Cheap-can’t patent it

Given orally

Low TI=2

Mech:

  • Alter glutamate metabolism
  • Decrease NE release
  • May alter 5HT

SE:

  • Short term
    • Tremors
    • Increase thirst
    • Increase urine prod. (block effects of ADH)
    • Edema
    • Weight gain
    • Nystagmus
  • Long term
    • Renal damage
    • Hypothyroidism

Toxicity:

  • Nausea
  • Delirium
  • Coma
  • Dangerous w/ kidney disorders
22
Q

Buproprion

A

Antidepressant

23
Q

Imipramine

A

First generation antidepressant

Tricyclic antidepressants

Mech: Inhibit NE reuptake

Act on multiple receptors

SE:

Most likely to cause SE
Sedation
Weight gain
Anticholinergic effect (dry eyes, dry mouth, constipation)
Cardiovascular effects

Arrythmias
Drop in BP (alpha1 block)
Orthostatic hypotension

24
Q

Amitriptyline

A

First generation antidepressant

Tricyclic antidepressants

Mech: Inhibit NE reuptake

Act on multiple receptors

SE:

Most likely to cause SE
Sedation
Weight gain
Anticholinergic effect (dry eyes, dry mouth, constipation)
Cardiovascular effects

Arrythmias
Drop in BP (alpha1 block)
Orthostatic hypotension

26
Q

Tranylcypromine

A

Antidepressant-MAO inhibitor

Mech: Irreversibly inhibits metab of NE and 5HT (via inhibition of MAO)

Kinetcs: Slow onset

Toxicity:

Insomnia
Agitation
Hallucination
Seizure
Liver toxicity
Weight gain
Hypotension
Great increase in likelihood of suicide in children

Drug interactions:

Indirect acting amines→Hypertensive crisis

Some foods contain tyramine (smoked foods, aged cheeses, wine)

27
Q

Phenelzine

A

Antidepressant-MAO inhibitor

Mech: Irreversibly inhibits metab of NE and 5HT (via inhibition of MAO)

Kinetcs: Slow onset

Toxicity:

Insomnia
Agitation
Hallucination
Seizure
Liver toxicity
Weight gain
Hypotension
Great increase in likelihood of suicide in children

Drug interactions:

Indirect acting amines→Hypertensive crisis

Some foods contain tyramine (smoked foods, aged cheeses, wine)

28
Q

Isocarboxazid

A

Antidepressant-MAO inhibitor

Mech: Irreversibly inhibits metab of NE and 5HT (via inhibition of MAO)

Kinetcs: Slow onset

Toxicity:

Insomnia
Agitation
Hallucination
Seizure
Liver toxicity
Weight gain
Hypotension
Great increase in likelihood of suicide in children

Drug interactions:

Indirect acting amines→Hypertensive crisis

Some foods contain tyramine (smoked foods, aged cheeses, wine)

Pharm 2 (8 decks)

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