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Behavior > Antidepressants > Flashcards

Antidepressants Flashcards

1
Q

MOA of SSRIs

A

increases serotonin levels by inhibiting serotonin reuptake at the synaptic cleft

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2
Q

side effects of and contraindications of

SSRIs

A

Sexual dysfunction
N/V/D
Agitation
Insomnia
Drowsiness
Weight Gain
SIADH/ hyponatremia
QT prolongation
HA
Serotonin Syndrome

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3
Q

MOA of SNRIs

A

Increases serotonin and Norepi by inhibiting serotonin and norepi reuptake at the synaptic cleft

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4
Q

Side effects of SNRI’s

(different from SSRIs)

A

Increased blood pressure
Sedation
Nausea

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5
Q

MOA of TCA’s

A
  1. Increases serotonin and Norepi by inhibiting serotonin and norepi reuptake at the synaptic cleft
  2. Inhibits fast cardiac sodium channels
  3. Inhibits Muscarinic AChR
  4. Inhibits Alpha1 Receptors
  5. Inhibits H1 Receptors
  6. Inhibits GABAA
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6
Q

Side effects of and contraindications of TCA’s

Specify which you see more in which category

A

Orthostatic hypotension
Cardiotoxicity: arrhythmias, prolonged QT, wide QRS
Tremor
Respiratory depression
Hyperpyrexia

More pronounced in tertiary TCA’s:

CVS: tachycardia, arrhythmia, hypotension
CNS: confusion, hallucinations, sedation, coma, seizures
GI: intestinal ileus, constipation
GU: urinary retention
Dry mouth
Dry eyes
Hyperthermia
Dry skin

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7
Q

MOA of MAOi’s

A

A: Decreases the breakdown of epi, norepi and serotonin to increase their levels by inhibiting monoamine oxidase

B: Selectively inhibits monoamine oxidase to increase levels of dopamine only

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8
Q

MAOi Side Effects and contraindications

A

CNS stimulation
Sexual dysfunction
Orthostatic hypotension
Weight gain

c/i: tyramine: red meat, wine, cheese= HTN Crisis

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9
Q

MOA of Mirtazapine

A

• Increases release of serotonin and norepi by selectively blocking alpha2
• Blocks 5-HT2 & 5-HT3 to increase the effect of serotonin on free 5-HT1 receptors (antidepressant action)
Acts as H1 antagonist

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10
Q

side effects of Mirtazapine

A

Increased appetite
Sedation
Increased cholesterol and triglycerides
Dry mouth

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11
Q

Indications for Mirtazapine

A

Major Depressive Disorder, especially in those who are underweight and/or those with insomnia

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12
Q

MOA of Bupropion

A

• Not fully understood
Increases dopamine and norepi via reuptake inhibition

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13
Q

Side effects and contraindications of Bupropion

A

Reduced seizure threshold
Tachycardia
Palpitations
Dry mouth
Weight loss
Insomnia
HA
Agitation

c/i: Seizures

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14
Q

Bupropion indications

A

Smoking cessation
Major depressive disorder

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15
Q

MOA of Vilazodone

A

• Increases serotonin by inhibiting serotonin reuptake in the synaptic cleft
Partial agonist of 5-HT1A receptors

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16
Q

side effects of Vilazodone

A

HA
N/V
Sleep disturbance
Sexual dysfunction
Dry mouth

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17
Q

MOA of Vortioxetine

A

• Increases serotonin by inhibiting serotonin
• Agonist of 5-HT1A receptors
Antagonist of 5-HT3 receptors

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18
Q

Side effects of Vortioxefine

A

Sexual dysfunction
Nausea
Abnormal dreams
Sleep disturbance

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19
Q

MOA of Varenicline

A

• Partial nicotinic Ach receptor agonist
Decreases nicotine cravings and withdrawal by stimulating dopamine activity

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20
Q

Side effects and contraindications of Varenicline

A

Mood disturbances
Sleep disturbances
Seizures

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21
Q

Indications for Varenicline

A

smoking cessation

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22
Q

Fluoxetine

A

SSRI

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23
Q

Paroxetine

A

SSRI

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24
Q

Sertraline

A

SSRI

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25
Q

Citalopram

A

SSRI

26
Q

Escitalopram

A

SSRI

27
Q

Fluvoxamine

A

SSRI

28
Q

Venlafaxine

A

SNRI

29
Q

Duloxetine

A

SNRI

30
Q

Desvenlafaxine

A

SNRI

31
Q

Levolinacipran

A

SNRI

32
Q

Milnacipran

A

SNRI

33
Q

Nortriptyline

A

Secondary TCA

34
Q

Desipramine

A

Secondary TCA

35
Q

Protriptyline

A

Secondary TCA

36
Q

Amoxapine

A

Secondary TCA

37
Q

Amitriptyline

A

Tertiary TCA

38
Q

Clomipramine

A

Tertiary TCA

39
Q

Doxepin

A

Tertiary TCA

40
Q

Imipramine

A

Tertiary TCA

41
Q

Trimipramine

A

Tertiary TCA

42
Q

Tranylcypromine

A

MAOI-A

43
Q

Phenelzine

A

MAOI-A

44
Q

Isocarboxazid

A

MAOI-A

45
Q

Selegiline

A

MAOI-B

46
Q

Mirtazapine

A

Atypical Antipsychotic

47
Q

Bupropion

A

Atypical Antipsychotic

48
Q

Vilazodone

A

Atypical Antipsychotic

49
Q

Vortioxetine

A

Atypical Antipsychotic

50
Q

Varenicline

A

Atypical Antipsychotic

51
Q

Indications of MAOis

A

3rd/4th line therapy for MDD

particularly effective in atypical depression

52
Q

which MAOI works particularly well in Parkinson Disease

A

Selegiline

53
Q

which TCA’s work best for DM peripheral neuropathy

A

Amitriptyline (3)

Desipramine (2)

54
Q

which TCA works well for OCD

A

Clomipramine (3)

55
Q

Which TCA’s work well for chronic pain, including fibromyalgia?

A

Amitriptyline (3)

Doxepin (3)

Imipramine (3)

Nortriptyline (2)

Desipramine (2)

56
Q

which TCA’s are used as second line treatment in bed wetting (enuresis)

A

Imipramine (3)

Amitriptyline (3)

Desipramine (2)

57
Q

Which TCA works well for insomnia

A

Doxepin

58
Q

Psychiatric Indications for SNRIs

A

Depression

General Anxiety Disorder

Social Anxiety Disorder

PTSD

OCD

59
Q

Which SNRI is used for fibromyalgia

A

Duloxetine

60
Q

Which SNRI is used for DM neuropathy

A

Venlafaxine

61
Q

What are SSRI’s used for

A

depression

generalized anxiety disorder

panic disorder

OCD

Bulimia

Social anxiety disorder

PTSD

62
Q

Trazadone

A

Atypical psychotic used for insomnia

Behavior (11 decks)

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