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Psychiatry Jeopardy Boards > Antidepressants > Flashcards

Antidepressants Flashcards

1
Q

The half-life of this SSRI is about one week

A

fluoxetine (prozac)

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2
Q

SSRI is the abbreviation for this

A

Selective Serotonin Reuptake Inhibitor

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3
Q

If an SSRI with a short half life
is abruptly stopped it
may result in this

A

Discontinuation Syndrome

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4
Q

SSRI’s and MAOI’s used in combination carry a high

risk of this side effect

A

serotonin syndrome

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5
Q

This is the most likely SSRI
to cause the side effect
of weight gain

A

paroxetine (paxil)

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6
Q

The washout period when
switching from an MAOI
to any SSRI is this

A

2 weeks

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7
Q

This SSRI is the S-enantiomer of citalopram (celexa)

A

escitalopram (lexapro)

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8
Q

These two SSRI’s have very
short half lives & should
be tapered to be
discontinued

A

paroxetine (paxil) & fluvoxamine (luvox)

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9
Q 
This is a common side effect of 
all SSRI’s & the doctor should specifically ask about it as 
the patient may otherwise 
be too embarrassed to 
talk about it
A

sexual side effects

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10
Q

The mechanism of action of

SNRI’s is this

A

Serotonin Norepinephrine Reuptake Inhibitor

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11
Q

This SNRI is the psychoactive metabolite of another SNRI

A

desvenlafaxine (pristiq)

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12
Q

Whether the dose is very high,

moderate, or low, this neurotransmitter’s reuptake is blocked by venlafaxine (effexor)

A

serotonin

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13
Q 
At very high doses (>375mg/d) 
of venlafaxine (effexor) this neurotransmitter’s reuptake 
may begin to be blocked
A

dopamine

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14
Q

This SNRI is preferred for painful symptoms of depression or diabetic neuropathy pain

A

duloxetine (cymbalta)

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15
Q

Patients taking SNRI’s for depression have an initial response, but then experience this

A

poop-out syndrome (relapse)

Also seen with SSRIs

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16
Q

As with all antidepressants, a depressed patient started on an SNRI who experiences activation & agitation may be having this

A

induced bipolar state

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17
Q

While venlafaxine (effexor) may cause the side effect of sweating, ironically it may be helpful to perimenopausal women with this

A

hot flashes/flushes

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18
Q

Venlafaxine (effexor) has
this relatively common, dose
dependent, cardiac system
related side effect

A

increased blood pressure

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19
Q

This medication is the most

well known NDRI (norepinephrine-dopamine reuptake inhibitor)

A

Bupropion (Wellbutrin)

20
Q

NDRI’s are useful in treating cravings from dependence

on this substance

A

nicotine (useful in treating smoking cessation)

21
Q

Not only do NDRI’s not have this common SSRI side effect, NDRI’s may be used to treat patients who have this SSRI side effect

A

Sexual dysfunction

22
Q

Like most anti-depressants, at typical doses NDRI’s carry a small risk of this serious side effect but the risk increases from 0.4% to 4% at very
high doses

A

Seizure

23
Q

Compared to SSRI’s or SNRI’s,
NDRI’s are less effective
in treating this class of
psychiatric illnesses

A

Anxiety Disorders

24
Q

NDRI’s may be especially helpful in treating this sleep disturbance that is seen in atypical depression

A

Hypersomnia (> 10 hours/nite)

25
Q

NDRI’s commonly do this

to a patient’s weight

A

Decrease (or no change)

26
Q

While not a first line treatment,

NDRI’s “stimulating” effects may be helpful in treating children and adults with this disorder

A

Attention Deficit Hyperactivity Disorder (ADHD)

27
Q

Onset of therapeutic action for NDRIs is usually not immediate, but is delayed until this time period

A

2-4 weeks

28
Q

NaSSA stands for this

A

Noradrenergic and Specific Serotonergic Agent

29
Q

NaSSA’s novel mechanism of action by which norepinephrine and serotonin system activity is increased is this

A

Pre-synaptic alpha 2 adrenergic antagonist

30
Q 
The medication that is in the 
NaSSA class is this
A

mirtazepine (remeron)

31
Q

SSRIs or venlafaxine (effexor) may cause these common side effects which NaSSA’s 5HT3 antagonism may help reduce or remove

A

GI side effects (nausea, diarrhea, stomach cramps)

32
Q

This mirtazapine (remeron) side effect is more likely in women than men, before menopause than after, and is unlikely to be a problem if it has not occurred within the first 6 weeks of treatment

A

weight gain

33
Q

Patients taking mirtazapine (remeron) and an MAO-I at the same time, or within 2 weeks
of the other, are at risk for
this serious side effect

A

serotonin syndrome

34
Q

Mirtazapine (remeron)

is an antagonist of what receptors?

A

a presynaptic receptor, serotonin post synaptic receptors, and histamine post synaptic receptor

35
Q

NaSSA onset of therapeutic effect on insomnia and anxiety is typically in this time period

A

almost immediately

36
Q

The cytochrome P450 enzyme system that is significantly effected by mirtazepine (remeron) is

A

None!

37
Q

A tertiary amine, amitriptyline (elavil), is metabolized to a secondary amine which is
this TCA

A

nortriptyline (pamelor)

38
Q

Blurred vision, urinary hesitancy, dry mouth, and constipation are due to this neurotransmitter receptor activity by TCA’s

A

anticholinergic activity

39
Q

A tertiary amine, imipramine (tofranil), is metabolized to a secondary amine which is
this TCA

A

desipramine (norpramin)

40
Q

TCA’s may be more effective than SSRI’s in treating depression for this sex of the clinical population

A

Men

41
Q

Fluoxetine (prozac), paroxetine (paxil), bupropion (wellbutrin), duloxetine (cymbalta) and other medications may increase all TCA’s concentration by
inhibiting this p450 enzyme

A

cytochrome p450 2D6

42
Q

Which psych drugs inhibit cytochrome p450 2D6, increasing TCA concentration?

A

Fluoxetine (prozac), paroxetine (paxil), bupropion (wellbutrin), duloxetine (cymbalta)

43
Q

Side effects of dizziness, sedation, and hypotension likely result from TCA’s antagonist activity
of this receptor

A

alpha adrenergic-1 receptor

44
Q

Side effects of sedation and weight gain from TCA’s are likely due to antagonist activity at this receptor

A

histamine (H1)

45
Q

TCA’s mechanism of action for treating depression is this

A

serotonin and norepinephrine reuptake inhibition

46
Q

The dangerous side effects from a TCA overdose are cardiac arrhythmias caused by
blockade of this

A

sodium channels

Psychiatry Jeopardy Boards (7 decks)

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