Antidepressants

Question 1

-Use in bipolar as mood stabilizer -Dulls neuotransmission via GABA -Contra: severe hepatic Dz, -A/E: HA, drowsiness, insomnia,

Answer 1

Anticonvulsants

Question 2

-SSRI–> more available -Low toxicity in OD -A/E: GI upset, sexual dysfunction, HA, changes in weight. -Citalopram avoid in those with prolonged QT -Contra: MOAI -2+ weeks to efficacy

Answer 2

SSRI

Question 3

-Used as a mood stabilizer -Exact MOA unknown. -Contra: Decreased renal function, pregnancy -s/e: leukocytosis, polyuria/dipsia, tremor, confusion, hypothyroid -Must monitor levels -Antimanic effect in 5-7 days, full 10-21

Answer 3

Lithium

Question 4

-Inhibit serotonin, norepi and dopamine -May be firstling for those with significant fatigue/pain sx -S/e: HTN, sexual dysfunction, sedation -Contra: MOAI -6weeks to efficacy. -Good for pain

Answer 4

SNRIs

Question 5

-Inhibits uptake of dopamine and norepi -S/e: lowers sz threshold, nervousness, tremor. -Contra: Epilepsy -Good for pts with parkinsons -4-6 weeks to efficacy

Answer 5

Bupropion

Question 6

-Inhibits reuptake of serotonins & norepi -Severe toxicity in overdose -s/e: anticholinergic effects, sedation, weight gain, prolongation of QT -Contra: MAOI, recent MI, Sz Hx -Fully effective 4-8 weeks

Answer 6

Tricyclics

Question 7

-Blocks breakdown of neurotransmitters: inhibits monoamine oxidase -S/E: HTN crisis (avoid tyramine-containing foods), Drowsiness, orthostatic hypotension, blurred vision, dysuria -Contra: SSRI, -4-6 weeks to see effects

Answer 7

Monoamine Oxidase Inhibitors