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Summer Pharm - Exam 2 > Antidepressants > Flashcards

Antidepressants Flashcards

1
Q

behaviors linked to mood disorders

A

pleasure

interests

libido

guilt

suicidality

sleep

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2
Q

behaviors linked to insomnia

A

memory

alertness

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3
Q

behaviors linked to psychoses

A

delusions

hallucinations

negative sx

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4
Q

behaviors linked to anxiety

A

obsessions

compulsions

ruminations

worry

fear

anxiety

pain

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5
Q

behaviors linked to substance use disorders

A

euphoria

reward

motivation

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6
Q

NE, serotonin, and dopamine are all linked to what behaviors

A

anxiety

irritability

mood

emotion

cognitive fxn

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7
Q

70% of depressed patients present to PCP w. only __ complaints

A

somatic

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8
Q

types of dpn’s

A

mdd/unipolar disorder

dysthymia

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9
Q

mdd usually responds specifically to (2)

A

electroconvulsive therapy (ECT)

antidepressants

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10
Q

milder form of dpn w. no long-term responses to drug therapy

A

dysthymia

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11
Q

t/f: even tho dysthymia has shown no long term response to drug therapy, pharmacotherapy is usually needed

A

T!

it is superior to placebo

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12
Q

most important factor when deciding on tx for dpn

A

symptoms

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13
Q

2 strategies for treatment resistant dpn

A

switching antidepressants

combining antidepressants

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14
Q

tx for treatment resistant dpn

A

buspirone

aripiprazole/olanzapine/quetiapine

lamotrigine

lithium

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15
Q

dsm dx for dpn includes __ sx

for at least __ weeks

A

5/9

2

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16
Q

sx of dpn

A

sigecaps

sleep → too much or too little

interest → anhedonia

guilt → increased

energy

concentration

appetite → increased or decreased

psychomotor agitation/retardation

suicidal ideation

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17
Q

classes of antidepressants

A

SSRIs

NDRIs

SNRIs

5HT partial agonist SSRI

TCADs

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18
Q

SSRIs to know

A

sertraline → zoloft

escitalopram → lexapro

fluoxetine → prozac

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19
Q

5HT partial agonist SSRI

A

trazodone

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20
Q

MAOI

A

phenelzine

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21
Q

NDRI

A

bupropion → wellbutrin

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22
Q

SNRIs

A

duloxetine → cymbalta

venlafaxine → effexor XR

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23
Q

which antidepressant is an alpha 2 antagonist

A

mirtazapine

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24
Q

which antidepressant is an alpha 1 receptor antagonist

A

TCAD → amytriptyline

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25
which antidepressant targets DA reuptake
NDRI -\> bupropion
26
which antidepressant classes target NE reuptake
SNRIs NDRIs TCADs
27
which antidepressant classes target 5HT (serotonin) reuptake
SSRIs SNRIs TCADs 5HT-SSRI
28
which antidepressant has antimuscarinic action
TCADs → amitryptyline
29
which 2 antidepressants have sedative action
trazodone mirtazipine
30
antidepressant that has contraindication if hx of seizure
NDRI → bupropion
31
moa for ketamine
NMDA receptor antagonist
32
ketamine can be used for __ dpn
treatment resistant
33
moa for brexanolone
neuroactive steroid (NAS)
34
what can brexanolone (zulresso) be used for
post partum dpn
35
cons of brexanolone (zulresso)
sedation LOC
36
acute s.e of SSRIs
nausea/diarrhea activation insomnia restlessness
37
delayed onset s.e of SSRIs
weight gain sexual dysfxn cognitive blunting
38
SSRIs have very low likelihood of fatalities, but what are withdrawal sx
flu like
39
severity of SSRI sx are related to
t½
40
s.e of SNRIs to know
HTN anxiety
41
t/f SNRIs have more rapid appearance of withdrawal sx than SSRIs
T!
42
s.e of NDRI (bupropion)
tremor anxiety insomnia **seizures at high doses**
43
s.e f trazodone
drowsiness
44
what antidepressant is used empirically as a hypnotic agent in depressed pt's
trazodone
45
s.e of mirtazapine
somnolence wt gain
46
which antidepressant has declining use d.t lots of s.e
TCAD → sedation antimuscarinic orthostatic hypotn weight gain
47
s.e of TCAD o.d
arrhythmias → sudden death seizures
48
common s.e of MAOI
postural hypotn
49
s.e of MAOI od
sz shock hyperthermia
50
s.e of ketamine
elevated bp
51
2 contraindications for ketamine
AV malformation hx of ICH
52
which antidepressant is a class III controlled substance
ketamine
53
most antidepressant agents have additive CNS depressant effects when combined w.
other sedatives
54
MAOIs can cause hypertensive crisis when combined w.
decongestants foods high in tyramine *dt acute increase in NE release*
55
what 2 drugs can cause serotonin syndrome
SSRIs MAOIs also SSRIs OR MAOIs combined w. meperidine, tramadol, dextromethorphan
56
sx of serotonin syndrome
hyperthermia muscle rigidity myoclonus AMS
57
what antidepressant inhibits P450 drug metabolism
SSRIs
58
how does St. John's Wort affect P450 drug metabolism
induces P450 drug metabolizing enzymes
59
which antidepressants have incomplete absorption dt significant 1st pass effect and wide variations in Cp (3)
SSRIs TCADs
60
1st line tx for dpn
SSRIs → sertraline fluoxetine citalopram escitalopram → lexapro
61
\_\_ may be more effective for dpn, but have more s.e
SNRIs → esp venlaxafine
62
\_\_ has less weight gain and sexual s.e than SSRIs and SNRIs, but is not effective for \_\_
bupropion anxious dpn
63
antidepressant that is good for dpn PLUS insomnia
mirtazapine
64
most rapid and effective tx for severe acute dpn
ect (electroconvulsive therapy)
65
frequency and duration of ECT
6-12 tx 2-3/week
66
adverse effects of ECT
cardiopulmonary fx orodental injuries HA confusion retrograde/anterograde amnesia
67
best antidepressant for pt who c/o chronic pain
TCADs

Summer Pharm - Exam 2 (12 decks)

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