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Summer Pharm - Exam 2 > Antidepressants > Flashcards

Antidepressants Flashcards

1
Q

behaviors linked to mood disorders

A

pleasure

interests

libido

guilt

suicidality

sleep

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2
Q

behaviors linked to insomnia

A

memory

alertness

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3
Q

behaviors linked to psychoses

A

delusions

hallucinations

negative sx

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4
Q

behaviors linked to anxiety

A

obsessions

compulsions

ruminations

worry

fear

anxiety

pain

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5
Q

behaviors linked to substance use disorders

A

euphoria

reward

motivation

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6
Q

NE, serotonin, and dopamine are all linked to what behaviors

A

anxiety

irritability

mood

emotion

cognitive fxn

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7
Q

70% of depressed patients present to PCP w. only __ complaints

A

somatic

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8
Q

types of dpn’s

A

mdd/unipolar disorder

dysthymia

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9
Q

mdd usually responds specifically to (2)

A

electroconvulsive therapy (ECT)

antidepressants

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10
Q

milder form of dpn w. no long-term responses to drug therapy

A

dysthymia

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11
Q

t/f: even tho dysthymia has shown no long term response to drug therapy, pharmacotherapy is usually needed

A

T!

it is superior to placebo

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12
Q

most important factor when deciding on tx for dpn

A

symptoms

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13
Q

2 strategies for treatment resistant dpn

A

switching antidepressants

combining antidepressants

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14
Q

tx for treatment resistant dpn

A

buspirone

aripiprazole/olanzapine/quetiapine

lamotrigine

lithium

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15
Q

dsm dx for dpn includes __ sx

for at least __ weeks

A

5/9

2

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16
Q

sx of dpn

A

sigecaps

sleep → too much or too little

interest → anhedonia

guilt → increased

energy

concentration

appetite → increased or decreased

psychomotor agitation/retardation

suicidal ideation

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17
Q

classes of antidepressants

A

SSRIs

NDRIs

SNRIs

5HT partial agonist SSRI

TCADs

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18
Q

SSRIs to know

A

sertraline → zoloft

escitalopram → lexapro

fluoxetine → prozac

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19
Q

5HT partial agonist SSRI

A

trazodone

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20
Q

MAOI

A

phenelzine

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21
Q

NDRI

A

bupropion → wellbutrin

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22
Q

SNRIs

A

duloxetine → cymbalta

venlafaxine → effexor XR

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23
Q

which antidepressant is an alpha 2 antagonist

A

mirtazapine

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24
Q

which antidepressant is an alpha 1 receptor antagonist

A

TCAD → amytriptyline

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25
Q

which antidepressant targets DA reuptake

A

NDRI -> bupropion

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26
Q

which antidepressant classes target NE reuptake

A

SNRIs

NDRIs

TCADs

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27
Q

which antidepressant classes target 5HT (serotonin) reuptake

A

SSRIs

SNRIs

TCADs

5HT-SSRI

28
Q

which antidepressant has antimuscarinic action

A

TCADs → amitryptyline

29
Q

which 2 antidepressants have sedative action

A

trazodone

mirtazipine

30
Q

antidepressant that has contraindication if hx of seizure

A

NDRI → bupropion

31
Q

moa for ketamine

A

NMDA receptor antagonist

32
Q

ketamine can be used for __ dpn

A

treatment resistant

33
Q

moa for brexanolone

A

neuroactive steroid (NAS)

34
Q

what can brexanolone (zulresso) be used for

A

post partum dpn

35
Q

cons of brexanolone (zulresso)

A

sedation

LOC

36
Q

acute s.e of SSRIs

A

nausea/diarrhea

activation insomnia

restlessness

37
Q

delayed onset s.e of SSRIs

A

weight gain

sexual dysfxn

cognitive blunting

38
Q

SSRIs have very low likelihood of fatalities, but what are withdrawal sx

A

flu like

39
Q

severity of SSRI sx are related to

A

t½

40
Q

s.e of SNRIs to know

A

HTN

anxiety

41
Q

t/f SNRIs have more rapid appearance of withdrawal sx than SSRIs

A

T!

42
Q

s.e of NDRI (bupropion)

A

tremor

anxiety

insomnia

seizures at high doses

43
Q

s.e f trazodone

A

drowsiness

44
Q

what antidepressant is used empirically as a hypnotic agent in depressed pt’s

A

trazodone

45
Q

s.e of mirtazapine

A

somnolence

wt gain

46
Q

which antidepressant has declining use d.t lots of s.e

A

TCAD →

sedation

antimuscarinic

orthostatic hypotn

weight gain

47
Q

s.e of TCAD o.d

A

arrhythmias → sudden death

seizures

48
Q

common s.e of MAOI

A

postural hypotn

49
Q

s.e of MAOI od

A

sz

shock

hyperthermia

50
Q

s.e of ketamine

A

elevated bp

51
Q

2 contraindications for ketamine

A

AV malformation

hx of ICH

52
Q

which antidepressant is a class III controlled substance

A

ketamine

53
Q

most antidepressant agents have additive CNS depressant effects when combined w.

A

other sedatives

54
Q

MAOIs can cause hypertensive crisis when combined w.

A

decongestants

foods high in tyramine

dt acute increase in NE release

55
Q

what 2 drugs can cause serotonin syndrome

A

SSRIs

MAOIs

also SSRIs OR MAOIs combined w. meperidine, tramadol, dextromethorphan

56
Q

sx of serotonin syndrome

A

hyperthermia

muscle rigidity

myoclonus

AMS

57
Q

what antidepressant inhibits P450 drug metabolism

A

SSRIs

58
Q

how does St. John’s Wort affect P450 drug metabolism

A

induces P450 drug metabolizing enzymes

59
Q

which antidepressants have incomplete absorption dt significant 1st pass effect and wide variations in Cp (3)

A

SSRIs

TCADs

60
Q

1st line tx for dpn

A

SSRIs →

sertraline

fluoxetine

citalopram

escitalopram → lexapro

61
Q

__ may be more effective for dpn, but have more s.e

A

SNRIs → esp venlaxafine

62
Q

__ has less weight gain and sexual s.e than SSRIs and SNRIs,

but is not effective for __

A

bupropion

anxious dpn

63
Q

antidepressant that is good for dpn PLUS insomnia

A

mirtazapine

64
Q

most rapid and effective tx for severe acute dpn

A

ect (electroconvulsive therapy)

65
Q

frequency and duration of ECT

A

6-12 tx

2-3/week

66
Q

adverse effects of ECT

A

cardiopulmonary

fx

orodental injuries

HA

confusion

retrograde/anterograde amnesia

67
Q

best antidepressant for pt who c/o chronic pain

A

TCADs

Summer Pharm - Exam 2 (12 decks)

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