Anticoagulants - The oral agents

Question 1

What are anticoagulants?

Answer 1

Medicines that help prevent blood clots.

Question 2

What are blood clots?

Answer 2

A seal created by blood to stop bleeding from wounds.

Question 3

How do anticoagulants work?

Answer 3

They interrupt the process that form blood clots

Question 4

What are names of antiplatelet medication?

Answer 4

Low-dose aspirin and Clopidogrel

Question 5

What is the most commonly prescribed anticoagulant?

Answer 5

Warfarin

Question 6

What is atrial fibrillation?

Answer 6

An irregular and often very rapid heart rhythm that can lead to blood clots

Question 7

What is a type of Direct Thrombin Antagonist?

Answer 7

Dabigatran

Question 8

What are examples of a factor Xa Antagonist?

Answer 8

• Apixaban
• Rivaroxaban

Question 9

What is an example of a Vitamin K inhibitor?

Answer 9

Warfarin

Question 10

What is the action of anticoagulants?

Answer 10

They reduce the formation of a fibrin clot, done by reducing thrombin activity

Question 11

What does Warfarin do?

Answer 11

Inhibits vitamin K epoxide reductase, subunit 1 and reduces circulating levels of protein c and s

Question 12

What is the interaction of Rivaroxaban with NSAIDs?

Answer 12

There is no increase in bleeding or impairment of either drug’s activity

Question 13

What is the interaction of Rivaroxaban and Aspirin?

Answer 13

No increase in bleeding risk or impairment of either drugs activity

Question 14

Why does Dabigatran cause more GI bleeding?

Answer 14

This could be due to the formulation being very acidic